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Myeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis with a unique imaging presentation of organizing pneumonia: A case report
- Source :
- Respiratory Medicine Case Reports, Vol 31, Iss, Pp 101294-(2020), Respiratory Medicine Case Reports
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) constitutes a group of blood vessel inflammation diseases of autoimmune origin. Myeloperoxidase (MPO) ANCA is closely related to ANCA associated AAV. The MPO-ANCA positive AAV patients have lung involvement at high rates; however, there are only a few reported cases with organizing pneumonia (OP). A 78-year-old man was presented to our hospital due to a fever of 38 °C despite a whole month of antibiotics treatment. Chest computed tomography image revealed restricted consolidations visible in the middle lobe of the right lung and the upper lobe of the left lung, which suggested an OP pattern. MPO-ANCA and urine occult blood tests were positive. Histopathological examination of the transbronchial biopsy revealed OP and mucus plug. Histological findings on renal biopsy showed necrotizing glomerulonephritis related to AAV. The patient was diagnosed with MPO-ANCA positive AAV and was treated with systemic corticosteroid therapy, from which he recovered rapidly. Thus, when diagnosing OP, the possibility of AAV should be considered by ordering patients’ serum ANCA and occult hematuria tests.
- Subjects :
- Pulmonary and Respiratory Medicine
Pathology
medicine.medical_specialty
BMI, body mass index
IP, interstitial pneumonia
MPO, myeloperoxidase
Case Report
Inflammation
urologic and male genital diseases
MPA, microscopic polyangiitis
medicine
ANCA, anti-neutrophil cytoplasmic antibody
cardiovascular diseases
UIP, usual interstitial pneumonia
EGPA, eosinophilic granulomatosis with polyangiitis
GPA, granulomatosis with polyangiitis
Organizing pneumonia
Anti-neutrophil cytoplasmic antibody
lcsh:RC705-779
Lung
AAV, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis
biology
medicine.diagnostic_test
business.industry
ANCA associated Vasculitis
lcsh:Diseases of the respiratory system
medicine.disease
Occult
CT, computed tomography
respiratory tract diseases
MPO-ANCA
medicine.anatomical_structure
Myeloperoxidase
CRP, C-reactive protein
biology.protein
Renal biopsy
medicine.symptom
Vasculitis
business
Blood vessel
Subjects
Details
- ISSN :
- 22130071
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Respiratory Medicine Case Reports
- Accession number :
- edsair.doi.dedup.....eb3134177b155c6ee401ab14fece1fb1