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Risk factors for Pseudomonas aeruginosa colonization in cystic fibrosis patients

Authors :
Eitan Kerem
Henry Levison
Mary Corey
Renato T. Stein
Ron Gold
Source :
The Pediatric Infectious Disease Journal. 9:494-498
Publication Year :
1990
Publisher :
Ovid Technologies (Wolters Kluwer Health), 1990.

Abstract

In an attempt to study the association between Pseudomonas aeruginosa colonization and clinical factors present before colonization, we studied 502 patients who attended our cystic fibrosis (CF) clinic between 1975 and 1988 and who were not colonized with P. aeruginosa before the study period. Twelve percent of the patients became colonized with P. aeruginosa before the age of 1 year and 44% by the age of 7 years. In a birth cohort followed from diagnosis during the study period, 23% were colonized with P. aeruginosa before age 1 year and 67% before age 7 years. Early P. aeruginosa colonization was associated with early diagnosis of CF. Presence of meconium ileus, gastrointestinal symptoms and pancreatic insufficiency at the time of diagnosis was also associated with early colonization. There was no association between the presence of respiratory symptoms at the time of diagnosis and age at first P. aeruginosa colonization. In families in which more than one sibling had CF, the age of P. aeruginosa acquisition was similar in the first colonized and the subsequently colonized siblings. In the year before the colonization patients with P. aeruginosa who were older than 1 year had higher rates of hospitalization and spent more days in hospital compared with patients without P. aeruginosa. In conclusion most P. aeruginosa colonization occurs at a younger age than previously reported. Early age at diagnosis and presence of CF-associated gastrointestinal abnormalities increase the likelihood of earlier colonization of P. aeruginosa.

Details

ISSN :
08913668
Volume :
9
Database :
OpenAIRE
Journal :
The Pediatric Infectious Disease Journal
Accession number :
edsair.doi.dedup.....eb373d0e5fd7e69bf9812563b6cc5c3a
Full Text :
https://doi.org/10.1097/00006454-199007000-00008