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Zebrafish, Medaka and Turquoise Killifish for Understanding Human Neurodegenerative/Neurodevelopmental Disorders
- Source :
- International Journal of Molecular Sciences, Vol 23, Iss 1399, p 1399 (2022)
- Publication Year :
- 2021
-
Abstract
- In recent years, small fishes such as zebrafish and medaka have been widely recognized as model animals. They have high homology in genetics and tissue structure with humans and unique features that mammalian model animals do not have, such as transparency of embryos and larvae, a small body size and ease of experiments, including genetic manipulation. Zebrafish and medaka have been used extensively in the field of neurology, especially to unveil the mechanisms of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease, and recently, these fishes have also been utilized to understand neurodevelopmental disorders such as autism spectrum disorder. The turquoise killifish has emerged as a new and unique model animal, especially for ageing research due to its unique life cycle, and this fish also seems to be useful for age-related neurological diseases. These small fishes are excellent animal models for the analysis of human neurological disorders and are expected to play increasing roles in this field. Here, we introduce various applications of these model fishes to improve our understanding of human neurological disorders.
- Subjects :
- animal structures
QH301-705.5
Autism Spectrum Disorder
Oryzias
Catalysis
Inorganic Chemistry
neurodegenerative disease
Fundulidae
small fish
Animals
Humans
Biology (General)
Physical and Theoretical Chemistry
QD1-999
Molecular Biology
Spectroscopy
Zebrafish
Mammals
medaka
Organic Chemistry
Neurodegenerative Diseases
General Medicine
Computer Science Applications
Chemistry
Parkinson’s disease
turquoise killifish
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 23
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....eb3eb8e763656e1c58939d88f09689d6