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Predictors of the Size of the Exchangeable Zinc Pool Differ between Children and Adults
- Source :
- The Journal of Nutrition. 147:187-194
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background The size of the rapidly exchanging pool of body zinc has been suggested as having potential utility as a biomarker of zinc status. Knowledge of the relations of exchangeable zinc pool (EZP) size to relevant variables is necessary to adequately evaluate its use as a biomarker. Objective We used regression analysis to investigate associations of EZP with age, sex, body size, and zinc nutrition variables. Methods Data were compiled from 18 isotope tracer studies of zinc absorption in 247 children and adults (248 observations) in which EZP and relevant variables (e.g., weight, age, absorbed zinc) were measured. Linear regression analyses were performed separately on data from adults and children. Results In children, EZP was most strongly associated with weight (r = 0.78). The best-fitting regression models of EZP (R2 ≥ 0.68) had weight or age and weight-for-age z score as predictors. Other variables had little effect on EZP when controlling for weight. Absorbed zinc was observed to be a predictor of EZP only in zinc intervention trials of infants. The mean EZP/wt was 4 mg/kg between 8 and 120 mo of age. In adults, EZP was observed to vary in a complex manner with (in order of importance) age, absorbed zinc, weight, sex, and plasma zinc concentration. EZP data from zinc-deprived subjects were lower than the 95% prediction interval of a model of normative data. Conclusions EZP was observed to maintain a constant size relative to weight and was influenced only slightly by other factors in children. In contrast, EZP in adults varied with several factors, including absorbed zinc, and was statistically smaller in zinc-deprived individuals. The findings suggest that EZP may have utility as an indicator of zinc status in adults, but there is less evidence for this in children. Additional data are needed to reach a definitive conclusion.
- Subjects :
- Adult
Male
0301 basic medicine
Aging
Intervention trials
Medicine (miscellaneous)
chemistry.chemical_element
Zinc
Zinc absorption
Body size
Standard score
Models, Biological
03 medical and health sciences
Animal science
Linear regression
Body Size
Humans
Medicine
Child
Plasma zinc
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
Regression analysis
chemistry
Regression Analysis
Female
business
Subjects
Details
- ISSN :
- 00223166
- Volume :
- 147
- Database :
- OpenAIRE
- Journal :
- The Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....eb5e1ef6fd7a8131a6b0f7595341b0e8