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Fur-type transcriptional repressors and metal homeostasis in the cyanobacterium Synechococcus sp. PCC 7002
- Source :
- Frontiers in Microbiology, Vol 6 (2015), Frontiers in Microbiology
- Publication Year :
- 2015
- Publisher :
- Frontiers Media S.A., 2015.
-
Abstract
- Metal homeostasis is a crucial cellular function for nearly all organisms. Some heavy metals (e.g. Fe, Zn, Co, Mo) are essential because they serve as cofactors for enzymes or metalloproteins, and chlorophototrophs such as cyanobacteria have an especially high demand for iron. At excessive levels, however, metals become toxic to cyanobacteria. Therefore, a tight control mechanism is essential for metal homeostasis. Metal homeostasis in microorganisms comprises two elements: metal acquisition from the environment and detoxification or excretion of excess metal ions. Different families of metal-sensing regulators exist in cyanobacteria and each addresses a more or less specific set of target genes. In this study the regulons of three Fur-type and two ArsR-SmtB-type regulators were investigated in a comparative approach in the cyanobacterium Synechococcus sp. PCC 7002. One Fur-type regulator controls genes for iron acquisition (Fur); one controls genes for zinc acquisition (Zur); and the third controls two genes involved in oxidative stress (Per). Compared to other well-investigated cyanobacterial strains, however, the set of target genes for each regulator is relatively small. Target genes for the two ArsR-SmtB transcriptional repressors (SmtB (SYNPCC7002_A2564) and SYNPCC7002_A0590; ArsR) are involved in zinc homeostasis in addition to Zur. Their target genes, however, are less specific for zinc and point to roles in a broader heavy metal detoxification response.
- Subjects :
- Microbiology (medical)
Cyanobacteria
Regulator
lcsh:QR1-502
Repressor
Microbiology
lcsh:Microbiology
Botany
Metalloprotein
zinc homeostasis
Photosynthesis
Gene
Heavy metal detoxification
Fur
Original Research
chemistry.chemical_classification
biology
SmtB
ArsR
transcriptome profiling
Zur
biology.organism_classification
PER
Regulon
Biochemistry
chemistry
bacteria
iron homeostasis
Function (biology)
Subjects
Details
- Language :
- English
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Frontiers in Microbiology
- Accession number :
- edsair.doi.dedup.....eb62364e32e62022b4279af2112fff31
- Full Text :
- https://doi.org/10.3389/fmicb.2015.01217/full