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Contrast-enhanced ultrasound for imaging vasa vasorum: comparison with histopathology in a swine model of atherosclerosis
- Source :
- European Journal of Echocardiography, 11(8), 659-664. Oxford University Press, Scopus-Elsevier
- Publication Year :
- 2010
- Publisher :
- Oxford University Press (OUP), 2010.
-
Abstract
- Aim To evaluate the agreement between contrast-enhanced ultrasound imaging and histopathology in an animal model of atherosclerosis. Methods and results Atherosclerosis was studied in both femoral arteries of four Rapacz familial hypercholesterolaemia (RFH) swine. Contrast-enhanced ultrasound imaging of the eight femoral arteries was performed at baseline and at 5, 12, 26, and 43 weeks follow-up after percutaneous transluminal stimulation of atherosclerosis to assess the progression of intima-media thickness (IMT) and the density and extent of the vasa vasorum network. Contrast-enhanced ultrasound imaging allowed an early detection of atherosclerosis and showed a significant gradual progression of atherosclerosis over time. IMT increased from 0.22 ± 0.05 mm at baseline to 0.45 ± 0.06 mm ( P < 0.001) at follow-up. The density of the vasa vasorum network increased during follow-up and was significantly higher in advanced than in early atherosclerosis. The findings with contrast-enhanced ultrasound were confirmed by histopathological specimens of the arterial wall. Conclusion Contrast-enhanced ultrasound is effective for in vivo detection of vasa vasorum in atherosclerotic plaques in the RFH swine model. After stimulation of atherosclerosis, contrast-enhanced ultrasound demonstrated a significantly increased IMT and significantly increased density of the vasa vasorum network in the developing atherosclerotic plaque, which was validated by histology.
- Subjects :
- medicine.medical_specialty
Pathology
Time Factors
Arteriosclerosis
Swine
Contrast Media
Femoral artery
medicine.disease_cause
Hyperlipoproteinemia Type II
medicine.artery
medicine
Animals
Radiology, Nuclear Medicine and imaging
Radionuclide Imaging
Ultrasonography
business.industry
Vasa Vasorum
Ultrasound
General Medicine
medicine.disease
Vulnerable plaque
Disease Models, Animal
medicine.anatomical_structure
Atheroma
Intima-media thickness
Vasa vasorum
cardiovascular system
Disease Progression
Histopathology
Tunica Intima
Tunica Media
Cardiology and Cardiovascular Medicine
business
Contrast-enhanced ultrasound
Subjects
Details
- ISSN :
- 15322114 and 15252167
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- European Journal of Echocardiography
- Accession number :
- edsair.doi.dedup.....eb74ef8233590cbfc903be87c5ad2c70