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Hydrogen Sulfide Switch Phenomenon Regulating Autophagy in Cardiovascular Diseases
- Source :
- Cardiovascular Drugs and Therapy. 34:113-121
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Hydrogen sulfide (H2S), a novel gaseous signaling molecule, is a vital physiological signal in mammals. H2S protects the cardiovascular system via modulation of vasodilation, vascular remodeling, and inhibition of vascular calcification, and also has anti-atherosclerosis properties. Autophagy is a lysosomal-mediated intracellular degradation mechanism for excessive or abnormal proteins and lipids. The contribution of autophagy to normal and disease-state cell physiology is extremely complicated. Autophagy acts as a double-edged sword in the cardiovascular system. It can defend against damage to cells caused by environmental changes and it can also induce active cell death under certain conditions. In recent years, accumulating evidence indicates that H2S can up- or downregulate autophagy in many pathological processes, thereby switching from a harmful to a beneficial role. In this review, we summarize progress on understanding the mechanism by which H2S regulates autophagy in cardiovascular disease. We also discuss a H2S switch phenomenon that regulates autophagy and provides protection in cardiovascular diseases.
- Subjects :
- 0301 basic medicine
Cell physiology
Apoptosis
Vasodilation
030204 cardiovascular system & hematology
Cardiovascular System
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Autophagy
Animals
Humans
Medicine
Pharmacology (medical)
Hydrogen Sulfide
Vascular calcification
Pharmacology
Mechanism (biology)
business.industry
Cardiovascular Agents
General Medicine
equipment and supplies
Cell biology
030104 developmental biology
Cardiovascular Diseases
Active cell
Cardiology and Cardiovascular Medicine
business
Intracellular
Signal Transduction
Subjects
Details
- ISSN :
- 15737241 and 09203206
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Drugs and Therapy
- Accession number :
- edsair.doi.dedup.....eb76077f29bc1baf02fff23af3ea2969