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Paternal age of schizophrenia probands and endophenotypic differences from unaffected siblings
- Source :
- Psychiatry research, vol 219, iss 1, Schmeidler, J; Lazzeroni, LC; Swerdlow, NR; Ferreira, RP; Braff, DL; Calkins, ME; et al.(2014). Paternal age of schizophrenia probands and endophenotypic differences from unaffected siblings. Psychiatry Research, 219(1), 67-71. doi: 10.1016/j.psychres.2014.05.035. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/63m7s4s4
- Publication Year :
- 2014
- Publisher :
- eScholarship, University of California, 2014.
-
Abstract
- We evaluated the discrepancy of endophenotypic performance between probands with schizophrenia and unaffected siblings by paternal age at proband birth, a possible marker for de novo mutations. Pairs of schizophrenia probands and unaffected siblings (N=220 pairs) were evaluated on 11 neuropsychological or neurophysiological endophenotypes previously identified as heritable. For each endophenotype, the sibling-minus-proband differences were transformed to standardized scores. Then for each pair, the average discrepancy was calculated from its standardized scores. We tested the hypothesis that the discrepancy is associated with paternal age, controlling for the number of endophenotypes shared between proband and his or her sibling, and proband age, which were both associated with paternal age. The non-significant association between the discrepancy and paternal age was in the opposite direction from the hypothesis. Of the 11 endophenotypes only sensori-motor dexterity was significant, but in the opposite direction. Eight other endophenotypes were also in the opposite direction, but not significant. The results did not support the hypothesized association of increased differences between sibling/proband pairs with greater paternal age. A possible explanation is that the identification of heritable endophenotypes was based on samples for which schizophrenia was attributable to inherited rather than de novo/non-inherited causes. © 2014.
- Subjects :
- Proband
Adult
Male
Endophenotypes
Medical and Health Sciences
Article
Paternal Age
Sporadic schizophrenia
Clinical Research
Familial schizophrenia
medicine
Genetics
Humans
Copy-number variation
Sibling
Biological Psychiatry
De novo mutations
Genetic risk
Psychiatry
Copy number variants
Siblings
Psychology and Cognitive Sciences
Neuropsychology
Paternal age
medicine.disease
Brain Disorders
Psychiatry and Mental health
Mental Health
Schizophrenia
Endophenotype
Mutation
Female
Psychology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Psychiatry research, vol 219, iss 1, Schmeidler, J; Lazzeroni, LC; Swerdlow, NR; Ferreira, RP; Braff, DL; Calkins, ME; et al.(2014). Paternal age of schizophrenia probands and endophenotypic differences from unaffected siblings. Psychiatry Research, 219(1), 67-71. doi: 10.1016/j.psychres.2014.05.035. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/63m7s4s4
- Accession number :
- edsair.doi.dedup.....eb77460701b684bb9240a4b49ba7f477