Back to Search
Start Over
VGF expression by T lymphocytes in patients with Alzheimer's disease
- Source :
- Scopus-Elsevier, Oncotarget
- Publication Year :
- 2015
- Publisher :
- Impact Journals, LLC, 2015.
-
Abstract
- Secretion of VGF is increased in cerebrospinal fluid and blood in neurodegenerative disorders like Alzheimer's disease (AD) and VGF is a potential biomarker for these disorders. We have shown that VGF is expressed in peripheral T cells and is correlated with T cell survival and cytokine secretion. The frequency of VGF+CD3+ T cells increases with normal aging. We found an increased number of VGF-expressing T cells in patients with AD compared to aged healthy controls, which was associated with enhanced HbA1c levels in blood. Upon treatment with rivastigmine, T cell proliferation and VGF expression in AD patients decreased to the level found in controls. Moreover, rapamycin treatment in vitro reduced the number of VGF+CD3+ cells in AD patients to control levels.
- Subjects :
- Male
Gerontology
medicine.medical_specialty
CD3 Complex
T-Lymphocytes
CD3
T cell
T cells
Rivastigmine
Flow cytometry
Research Paper: Gerotarget (Focus on Aging)
Cerebrospinal fluid
Alzheimer Disease
Internal medicine
medicine
Humans
Nerve Growth Factors
Cells, Cultured
Aged
Cell Proliferation
Aged, 80 and over
Glycated Hemoglobin
Sirolimus
VGF expression
medicine.diagnostic_test
biology
rapamycin
Cell growth
business.industry
Alzheimer's disease
Flow Cytometry
medicine.disease
Neuroprotective Agents
Endocrinology
Nerve growth factor
medicine.anatomical_structure
Oncology
biology.protein
Female
Cytokine secretion
business
Biomarkers
Immunosuppressive Agents
Subjects
Details
- ISSN :
- 19492553
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....eb8b92d701dec99792ea36114a62eb83