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Neuropsychiatric Symptoms in Parkinsons Disease After Subthalamic Nucleus Deep Brain Stimulation
- Source :
- Frontiers in Neurology, Vol 12 (2021), Frontiers in Neurology
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- Background: Indications for subthalamic nucleus deep brain stimulation (STN-DBS) surgery are determined basically by preoperative motor function; however, postoperative quality of life (QOL) is not necessarily associated with improvements in motor symptoms, suggesting that neuropsychiatric symptoms might be related to QOL after surgery in patients with Parkinson's disease.Objectives: We aimed to examine temporal changes in neuropsychiatric symptoms and their associations with QOL after STN-DBS.Materials and Methods: We prospectively enrolled a total of 61 patients with Parkinson's disease (mean age = 65.3 ± 0.9 years, mean disease duration = 11.9 ± 0.4 years). Motor function, cognitive function, and neuropsychiatric symptoms were evaluated before and after DBS surgery. Postoperative evaluation was performed at 3 months, 1 year, and 3 years after surgery.Results: Of the 61 participants, 54 completed postoperative clinical evaluation after 3 months, 47 after 1 year, and 23 after 3 years. Frontal lobe functions, depression, and verbal fluency significantly worsened 3 years after STN-DBS. Non-motor symptoms such as impulsivity and the Unified PD Rating Scale (UPDRS) part I score were associated with QOL after STN-DBS.Conclusions: Frontal lobe functions, depression, and verbal fluency significantly worsened 3 years after STN-DBS. The UPDRS part I score and higher impulsivity might be associated with QOL after STN-DBS.
- Subjects :
- Pediatrics
medicine.medical_specialty
Deep brain stimulation
Parkinson's disease
medicine.medical_treatment
Disease
Impulsivity
behavioral disciplines and activities
Quality of life
medicine
Verbal fluency test
RC346-429
Depression (differential diagnoses)
Original Research
UPDRS
business.industry
medicine.disease
deep brain stimulation
nervous system diseases
surgical procedures, operative
quality of life
nervous system
Frontal lobe
Neurology
neuropsychiatric symptoms
Neurology. Diseases of the nervous system
Neurology (clinical)
medicine.symptom
business
therapeutics
Subjects
Details
- Language :
- English
- ISSN :
- 16642295
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neurology
- Accession number :
- edsair.doi.dedup.....eb902c5138106ad8d18ceda733d64d31
- Full Text :
- https://doi.org/10.3389/fneur.2021.656041