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Body fat distribution, in particular visceral fat, is associated with cardiometabolic risk factors in obese women
- Source :
- PLoS ONE, PLoS ONE, 12(9), PLoS ONE, Vol 12, Iss 9, p e0185403 (2017)
- Publication Year :
- 2017
- Publisher :
- Public Library of Science, 2017.
-
Abstract
- Background Body fat distribution is, next to overall obesity, an important risk factor for cardiometabolic outcomes in the general population. In particular, visceral adipose tissue (VAT) is strongly associated with cardiometabolic risk factors. Since it is unclear whether body fat distribution is also important in men and women with obesity we investigated the associations between measures of body fat distribution and cardiometabolic risk factors in men and women with obesity. Methods In this cross-sectional analysis of obese men and women (BMI≥30 kg/m2) included in the Netherlands Epidemiology of Obesity Study, waist:hip ratio(WHR), waist circumference, and MRI-based abdominal subcutaneous adipose tissue (aSAT) and VAT were determined. Associations between measures of body fat distribution and presence of ≥1 risk factor, such as hypertension or hypertriglyceridemia, were examined using logistic regression analyses; stratified by sex and adjusted for age, ethnicity, education, tobacco smoking, alcohol consumption, physical activity and depending on the association additionally for total body fat or VAT. Results We included 2,983 obese individuals (57% women) with a mean age of 56 and standard deviation (SD) of 6 and mean BMI of 34.0 kg/m2 (4.0), after exclusion of individuals with missing values of cardiometabolic risk factors (n = 33). 241 individuals were obese without other cardiometabolic risk factors. In obese women, all measures of body fat distribution except aSAT (OR per SD:0.76, 95%CI: 0.53, 1.10) were associated with having ≥1 cardiometabolic risk factor, of which VAT most strongly associated (5.77; 3.02, 11.01). In obese men, associations of body fat distribution and the presence of cardiometabolic risk factors were attenuated. (e.g. VAT:1.42; 0.84, 2.41). Conclusions In obese women, but less so in men, measures of body fat distribution, of which VAT most strongly, are associated with cardiometabolic risk factors.
- Subjects :
- Male
Physiology
lcsh:Medicine
Adipose tissue
030204 cardiovascular system & hematology
Cardiovascular Medicine
Biochemistry
Diagnostic Radiology
Fats
0302 clinical medicine
Risk Factors
Medicine and Health Sciences
Odds Ratio
Medicine
Body Fat Distribution
Public and Occupational Health
lcsh:Science
Metabolic Syndrome
education.field_of_study
Multidisciplinary
Radiology and Imaging
Middle Aged
Lipids
Magnetic Resonance Imaging
Adipose Tissue
Physiological Parameters
Cardiovascular Diseases
Female
Anatomy
Research Article
medicine.medical_specialty
Waist
Imaging Techniques
Population
030209 endocrinology & metabolism
Intra-Abdominal Fat
Research and Analysis Methods
03 medical and health sciences
Classification of obesity
Diagnostic Medicine
Internal medicine
Cardiovascular Diseases in Women
Humans
Obesity
Risk factor
education
Aged
business.industry
lcsh:R
Body Weight
nutritional and metabolic diseases
Biology and Life Sciences
Health Risk Analysis
Odds ratio
Physical Activity
medicine.disease
Health Care
Endocrinology
Biological Tissue
Epidemiology of obesity
Women's Health
lcsh:Q
business
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....eb94e3858bd82f3c5d2dacc039288606