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The role of monoamine oxidase enzymes in the pathophysiology of neurological disorders
- Source :
- Journal of chemical neuroanatomy. 114
- Publication Year :
- 2020
-
Abstract
- Monoamine oxidase enzymes are responsible for the degredation of serotonin, dopamine, and norepinephrine in the central neurvous system. Although it has been nearly 100 years since they were first described, we are still learning about their role in the healthy brain and how they are altered in various disease states. The present review provides a survey of our current understanding of monoamine oxidases, with a focus on their contributions to neuropsychiatric, neurodevelopmental, and neurodegenerative disease. Important species differences in monoamine oxidase function and development in the brain are highlighted. Sex-specific monoamine oxidase regulatory mechanisms and their implications for various neurological disorders are also discussed. While our understanding of these critical enzymes has expanded over the last century, gaps exist in our understanding of sex and species differences and the roles monoamine oxidases may play in conditions often comorbid with neurological disorders.
- Subjects :
- 0301 basic medicine
Male
Monoamine Oxidase Inhibitors
Monoamine oxidase
Disease
03 medical and health sciences
Cellular and Molecular Neuroscience
Norepinephrine
0302 clinical medicine
Species Specificity
Dopamine
medicine
Animals
Humans
Monoamine Oxidase
Sex Characteristics
business.industry
medicine.disease
030104 developmental biology
Monoamine neurotransmitter
Autism spectrum disorder
Schizophrenia
Female
Serotonin
Nervous System Diseases
business
Neuroscience
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 18736300
- Volume :
- 114
- Database :
- OpenAIRE
- Journal :
- Journal of chemical neuroanatomy
- Accession number :
- edsair.doi.dedup.....ebbdbe5d135cfc154cc72af52574a87e