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Characteristics of a rat model of an open craniocerebral injury at simulated high altitude
- Source :
- Neuroreport
- Publication Year :
- 2014
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2014.
-
Abstract
- To establish a rat model of an open craniocerebral injury at simulated high altitude and to examine the characteristics of this model. Rats were divided randomly into a normobaric group and a high-altitude group and their corresponding control groups. A rat model of an open craniocerebral injury was established with a nail gun shot. Simulated high-altitude conditions were established with a hypobaric chamber at 0.6 ATA to mimic pressure at an altitude of 4000 m. Mortality, brain water content (BWC), Evans blue content, pathology, regional cerebral blood flow (rCBF), partial pressure of brain tissue oxygen (PbtO2), and brainstem auditory-evoked potential were observed after injury. The mortality of the high-altitude group was significantly greater than that of the normobaric group within 72 h after injury (P
- Subjects :
- Male
Rat model
Craniocerebral injury
Brain water
chemistry.chemical_compound
Altitude
high altitude
Evoked Potentials, Auditory, Brain Stem
Animals
Head Injuries, Penetrating
rCBF
Medicine
Rats, Wistar
Evans Blue
business.industry
animal model
General Neuroscience
Clinical Neuroscience
Brain
open craniocerebral injury
Effects of high altitude on humans
Rats
Disease Models, Animal
Atmospheric Pressure
Cerebral blood flow
chemistry
Hypobaric chamber
Anesthesia
brain water content
business
PbtO2
Subjects
Details
- ISSN :
- 09594965
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- NeuroReport
- Accession number :
- edsair.doi.dedup.....ebbea0cc6841a1670ca64b3d186556ca
- Full Text :
- https://doi.org/10.1097/wnr.0000000000000259