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Characteristics of a rat model of an open craniocerebral injury at simulated high altitude

Authors :
Yi Yin
Jiangkai Lin
Gang Zhu
Quan-Hong Xu
An-Yong Yu
Sheng-Li Hu
Fei Li
Yujie Chen
Hua Feng
Source :
Neuroreport
Publication Year :
2014
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2014.

Abstract

To establish a rat model of an open craniocerebral injury at simulated high altitude and to examine the characteristics of this model. Rats were divided randomly into a normobaric group and a high-altitude group and their corresponding control groups. A rat model of an open craniocerebral injury was established with a nail gun shot. Simulated high-altitude conditions were established with a hypobaric chamber at 0.6 ATA to mimic pressure at an altitude of 4000 m. Mortality, brain water content (BWC), Evans blue content, pathology, regional cerebral blood flow (rCBF), partial pressure of brain tissue oxygen (PbtO2), and brainstem auditory-evoked potential were observed after injury. The mortality of the high-altitude group was significantly greater than that of the normobaric group within 72 h after injury (P

Details

ISSN :
09594965
Volume :
25
Database :
OpenAIRE
Journal :
NeuroReport
Accession number :
edsair.doi.dedup.....ebbea0cc6841a1670ca64b3d186556ca
Full Text :
https://doi.org/10.1097/wnr.0000000000000259