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Perioperative Blood Transfusion Is a Predictor of Acute and Chronic Renal Function Deterioration after Partial and Radical Nephrectomy for Renal Cell Carcinoma
- Source :
- Urologia Internationalis. 104:775-780
- Publication Year :
- 2020
- Publisher :
- S. Karger AG, 2020.
-
Abstract
- Introduction: The aim was to evaluate the impact of perioperative blood transfusions (PBTs) on renal function after surgery for renal cell carcinoma (RCC). Methods: Consecutive patients with RCC who underwent partial nephrectomy or radical nephrectomy between 2005 and 2015 at a tertiary care center were included. Minimum follow-up period was 6 months. A PBT was defined as the transfusion of packed erythrocyte concentrate (EC) within 7 days before until 30 days after surgery. The multivariable analyses were carried out by Cox regression. Results: The overall cohort included 851 patients, of whom 93 (10.9%) received a PBT. The median follow-up was 46 months (range 28–72). In case of a PBT, a median of 2 EC was transfused. PBT patients were older and had a poorer performance status and more comorbidities as well as locally more advanced or metastatic tumors. In the multivariable analyses, PBT was an independent prognostic factor for acute as well as chronic renal impairment (hazard ratio (HR) 2.72, 95% confidence interval (95% CI) 1.45–5.10, p = 0.002 and HR 2.23, 95% CI 1.26–3.70, p = 0.007). Conclusion: PBT is associated with acute and chronic deterioration of kidney function after surgery for RCC. Thus, it may be used to identify patients requiring close nephrological monitoring.
- Subjects :
- Male
medicine.medical_specialty
Blood transfusion
Urology
medicine.medical_treatment
030232 urology & nephrology
Renal function
Kidney
Nephrectomy
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Renal cell carcinoma
Humans
Medicine
Postoperative Period
Carcinoma, Renal Cell
Aged
Retrospective Studies
Performance status
business.industry
Proportional hazards model
Hazard ratio
Perioperative
Middle Aged
Prognosis
medicine.disease
Kidney Neoplasms
030220 oncology & carcinogenesis
Acute Disease
Chronic Disease
Preoperative Period
Female
Erythrocyte Transfusion
business
Subjects
Details
- ISSN :
- 14230399 and 00421138
- Volume :
- 104
- Database :
- OpenAIRE
- Journal :
- Urologia Internationalis
- Accession number :
- edsair.doi.dedup.....ebc1e96d597a5347b439c13ef9187c6a
- Full Text :
- https://doi.org/10.1159/000509206