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Cardiovascular disease potentially contributes to the progression and poor prognosis of COVID-19
- Source :
- Nutrition, metabolism and cardiovascular diseases, In Press, Nutrition, Metabolism and Cardiovascular Diseases
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background and aim A novel coronavirus severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) caused pneumonia, Coronavirus Disease 2019 (COVID-19), broke out in Wuhan, China in December 2019, and spread all over the world. Patients with COVID-19 showed huge differences in the hospital stay, progression, and prognosis. As reported, the comorbidities may play an important role in COVID-19. Here, we aim to address the role of cardiovascular disease (CVD) in the progression and prognosis of COVID-19. Methods and results Eighty-three confirmed COVID-19 patients were divided into CVD (n = 42) and non-CVD (n = 41) group according to their medical history. Medical records including demographic data, medical history, clinical characteristics, laboratory examinations, chest computed tomography (CT), and treatment measures were collected, analyzed, and compared between the two groups. COVID-19 patients with CVD showed (1) more severe pathological changes in the lungs, (2) elevated injury-related enzymes including α-hydroxybutyrate dehydrogenase (HDBH), lactic dehydrogenase (LDH), γ-glutamyltransferase (GGT), creatine kinase (CK), and alanine aminotransferase (ALT), (3) significantly increased uncontrolled inflammation related markers, such as c-reactive protein (CRP), interleukin (IL)-6, serum ferritin, erythrocyte sedimentation rate (ESR), and serum amyloid A (SAA), (4) serious hypercoagulable status reflected by increased D-dimer and serum fibrinogen (FIB), and (5) higher mortality, compared to COVID-19 patients without CVD. Conclusions Our data indicated that CVD is a strong risk factor for rapid progression and bad prognosis of COVID-19. More intensive medical care should be applied to patients with CVD to prevent rapid deterioration of the disease.
- Subjects :
- Male
Databases, Factual
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Comorbidity
Disease
030204 cardiovascular system & hematology
Gastroenterology
Disease Outbreaks
Cohort Studies
0302 clinical medicine
Reference Values
Cause of Death
Cause of death
Nutrition and Dietetics
medicine.diagnostic_test
biology
Middle Aged
C-Reactive Protein
Cardiovascular Diseases
Erythrocyte sedimentation rate
Disease Progression
Female
Coronavirus Infections
Cardiology and Cardiovascular Medicine
COVID-19
Cardiovascular disease
prognosis
Adult
China
medicine.medical_specialty
Pneumonia, Viral
030209 endocrinology & metabolism
Betacoronavirus
03 medical and health sciences
Internal medicine
medicine
Humans
Medical history
Serum amyloid A
Risk factor
Pandemics
Aged
Retrospective Studies
SARS-CoV-2
business.industry
C-reactive protein
medicine.disease
Survival Analysis
Pneumonia
biology.protein
Tomography, X-Ray Computed
business
Biomarkers
Blood Chemical Analysis
Subjects
Details
- ISSN :
- 09394753
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Nutrition, Metabolism and Cardiovascular Diseases
- Accession number :
- edsair.doi.dedup.....ebc67155a756d6e4535aabe487b0d069
- Full Text :
- https://doi.org/10.1016/j.numecd.2020.04.013