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Differential expression of type I insulin-like growth factor receptors in different stages of human T cells
- Source :
- European Journal of Immunology. 25:931-935
- Publication Year :
- 1995
- Publisher :
- Wiley, 1995.
-
Abstract
- Insulin-like growth factor I (IGF-I) has been implicated to play a regulatory role in T cell development and in T cell function. We investigated the expression of type I IGF receptors on human peripheral T cells related to the maturation and activation stage using the type I IGF receptor-specific monoclonal antibody alpha IR3. It appeared that 87% of the CD4+CD45RA+ cells and 66% of the CD8+CD45RA+ cells were alpha IR3+, whereas only 37% of the CD4+CD45R0+ cells and 38% of the CD8+CD45R0+ cells bound alpha IR3. We also found that the fraction of alpha IR3+ cells within in vivo or in vitro activated (HLA-DR+) T cells is markedly lower than in nonactivated (HLA-DR-) cells. In vitro phytohemagglutinin-activated T cells and CD4+CD45R0+ cells activated with recall antigens also contained less alpha IR3+ cells (1-6%) than nonactivated cells (30-54%).
- Subjects :
- T-Lymphocytes
T cell
Immunology
Immunophenotyping
Receptor, IGF Type 1
Interleukin 21
Antigens, CD
T-Lymphocyte Subsets
medicine
Humans
Immunology and Allergy
Cytotoxic T cell
IL-2 receptor
Antigen-presenting cell
Cells, Cultured
Interleukin 3
CD40
biology
Cell Differentiation
Flow Cytometry
Molecular biology
Cell biology
medicine.anatomical_structure
biology.protein
Interleukin 12
Biomarkers
Subjects
Details
- ISSN :
- 15214141 and 00142980
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- European Journal of Immunology
- Accession number :
- edsair.doi.dedup.....ebc70f775c5c46e0d741a296c1073db3