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Neural effects of continuous theta-burst stimulation in macaque parietal neurons
- Publication Year :
- 2022
- Publisher :
- eLIFE SCIENCES PUBL LTD, 2022.
-
Abstract
- Theta-burst transcranial magnetic stimulation (TBS) has become a standard non-invasive technique to induce offline changes in cortical excitability in human volunteers. Yet, TBS suffers from a high variability across subjects. A better knowledge about how TBS affects neural activity in vivo could uncover its mechanisms of action and ultimately allow its mainstream use in basic science and clinical applications. To address this issue, we applied continuous TBS (cTBS, 300 pulses) in awake behaving rhesus monkeys and quantified its after-effects on neuronal recordings and behavior. Guided by anatomical MRI, we recorded single-cell activity in parietal area PFG during passive fixation of real-world objects. Overall, we observed a pronounced, long-lasting and highly reproducible reduction in neuronal excitability after cTBS in individual parietal neurons, with some neurons exhibiting periods of hyperexcitability during the recovery phase. We applied the same stimulation protocol during visually-guided grasping of objects, and observed a significant grasping impairment. These results provide the first experimental evidence on the effects of cTBS on single neurons in awake behaving monkeys.
- Subjects :
- Neurons
General Immunology and Microbiology
biology
General Neuroscience
medicine.medical_treatment
Gastropoda
CTBS
Stimulation
General Medicine
Macaca mulatta
Transcranial Magnetic Stimulation
Macaque
Healthy Volunteers
General Biochemistry, Genetics and Molecular Biology
Transcranial magnetic stimulation
Theta burst
Neural activity
biology.animal
Cortical Excitability
Fixation (visual)
medicine
Animals
Humans
Neuroscience
Recovery phase
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....ebd7b3a9a7780c82ba38511dde4c5c58