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Clinical Significance of Skin Autofluorescence in Elderly Patients With Long-Standing Persistent Atrial Fibrillation
- Source :
- Cardiology Research
- Publication Year :
- 2019
- Publisher :
- Elmer Press, 2019.
-
Abstract
- Background Recent clinical studies have demonstrated the importance of skin autofluorescence as a cardiovascular risk factor. However, data regarding the relationship between skin autofluorescence and atrial fibrillation are limited. The aim of this study was to clarify the clinical significance of skin autofluorescence in elderly patients with long-standing persistent atrial fibrillation. Methods This cross-sectional study enrolled 112 elderly patients with long-standing persistent atrial fibrillation who were treated medically (46 men and 66 women; mean age, 81 ± 9 years). The association between skin autofluorescence and various clinical parameters was examined. Results Significant relationships were observed between skin autofluorescence and CHADS2 score (r = 0.53, P < 0.001), high-sensitivity cardiac troponin T level (r = 0.43, P < 0.001), reactive oxygen metabolite levels (r = 0.52, P < 0.001), and whole blood passage time (r = 0.45, P < 0.001). Furthermore, multiple regression analyses showed that these clinical parameters were independent variables when skin autofluorescence was used as a subordinate factor. Receiver-operating characteristic curve analysis indicated that the risk values of skin autofluorescence for high CHADS2 scores (≥ 2) or elevated high-sensitivity cardiac troponin T levels (> 0.014ng/mL) were 2.6 arbitrary units (AU) and 2.7 AU, respectively. Conclusions The findings of this study indicated that skin autofluorescence may be a prognostic factor in elderly patients with long-standing persistent atrial fibrillation. The risk value of skin autofluorescence was considered as 2.6 AU or 2.7 AU.
- Subjects :
- 0301 basic medicine
Prognostic factor
medicine.medical_specialty
Arbitrary unit
030204 cardiovascular system & hematology
High-sensitivity cardiac troponin T
CHADS2 score
Blood rheology
03 medical and health sciences
Skin autofluorescence
0302 clinical medicine
Elderly
Internal medicine
Long-standing persistent atrial fibrillation
Medicine
Clinical significance
Risk factor
business.industry
Mean age
Atrial fibrillation
medicine.disease
030104 developmental biology
Oxidative stress
Persistent atrial fibrillation
Cardiology
Original Article
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 19232837 and 19232829
- Volume :
- 10
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cardiology Research
- Accession number :
- edsair.doi.dedup.....ebebfc2b5680b202b41236a89ce35a33