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Supramolecular hydrogel based on high-solid-content mPECT nanoparticles and cyclodextrins for local and sustained drug delivery
- Source :
- Biomaterials Science. 5:698-706
- Publication Year :
- 2017
- Publisher :
- Royal Society of Chemistry (RSC), 2017.
-
Abstract
- A novel injectable and high-solid-content drug-loaded supramolecular hydrogel (PTX-mPECT NP/α-CDgel) was prepared by self-assembly of inclusion complexes based on PTX-loaded mPECT (methoxy poly(ethylene glycol)-b-poly(e-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-un-decanone)) nanoparticles (PTX-mPECT NPs) and α-cyclodextrin (α-CD). Paclitaxel (PTX) was chosen as a hydrophobic drug encapsulated into mPECT NPs. Then, gelation occurred when the aqueous solution of α-CD was added to the PTX-mPECT NPs aqueous dispersion within several seconds after stirring. Importantly, with the erosion of the hydrogel, PTX-loaded NPs could be released again and then PTX released further. Rheological studies showed that PTX-mPECT NP/α-CDgel with good injectability underwent a shear-induced sol-gel transition. The results of in vitro drug-release studies demonstrated a sustained-release profile, and the cumulative release of PTX was ≈35% after 20 days. The results of cell-uptake studies and in vitro cytotoxicity studies indicated that the PTX-loaded NPs have been efficiently delivered to cells and killed tumor cells. Higher suppression of tumor growth demonstrated the remarkable anticancer effect of PTX-mPECT NP/α-CDgel upon peritumoral injection. These results showed that high-solid-content PTX-mPECT NP/α-CDgel based on in situ systems could be a promising candidate for local and sustained drug delivery.
- Subjects :
- alpha-Cyclodextrins
endocrine system
Paclitaxel
Cell Survival
Stereochemistry
Biomedical Engineering
Supramolecular chemistry
Nanoparticle
02 engineering and technology
010402 general chemistry
complex mixtures
01 natural sciences
Hydrogel, Polyethylene Glycol Dimethacrylate
Phase Transition
Injections
Polyethylene Glycols
Lactones
chemistry.chemical_compound
Cell Line, Tumor
Neoplasms
Animals
Humans
General Materials Science
Solid content
Caproates
Mice, Inbred BALB C
Aqueous solution
technology, industry, and agriculture
021001 nanoscience & nanotechnology
Antineoplastic Agents, Phytogenic
In vitro
0104 chemical sciences
chemistry
Delayed-Action Preparations
Drug delivery
Nanoparticles
0210 nano-technology
Ethylene glycol
HeLa Cells
Nuclear chemistry
Subjects
Details
- ISSN :
- 20474849 and 20474830
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Biomaterials Science
- Accession number :
- edsair.doi.dedup.....ebf92d50b68b5a17de6fc267a61deeb8