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Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels
- Source :
- PLoS ONE, Vol 7, Iss 12, p e53030 (2012), PLoS ONE, PLoS ONE; Vol 7
- Publication Year :
- 2012
-
Abstract
- PTX3 is a long pentraxin of the innate immune system produced by different cell types (mononuclear phagocytes, dendritic cells, fibroblasts and endothelial cells) at the inflammatory site. It appears to have a cardiovascular protective function by acting on the immune-inflammatory balance in the cardiovascular system. PTX3 plasma concentration is an independent predictor of mortality in patients with acute myocardial infarction (AMI) but the influence of PTX3 genetic variants on PTX3 plasma concentration has been investigated very little and there is no information on the association between PTX3 variations and AMI. Subjects of European origin (3245, 1751 AMI survivors and 1494 controls) were genotyped for three common PTX3 polymorphisms (SNPs) (rs2305619, rs3816527, rs1840680). Genotype and allele frequencies of the three SNPs and the haplotype frequencies were compared for the two groups. None of the genotypes, alleles or haplotypes were significantly associated with the risk of AMI. However, analysis adjusted for age and sex indicated that the three PTX3 SNPs and the corresponding haplotypes were significantly associated with different PTX3 plasma levels. There was also a significant association between PTX3 plasma concentrations and the risk of all-cause mortality at three years in AMI patients (OR 1.10, 95% CI: 1.01-1.20, p = 0.02). Our study showed that PTX3 plasma levels are influenced by three PTX3 polymorphisms. Genetically determined high PTX3 levels do not influence the risk of AMI, suggesting that the PTX3 concentration itself is unlikely to be even a modest causal factor for AMI. Analysis also confirmed that PTX3 is a prognostic marker after AMI.
- Subjects :
- Male
Heredity
Myocardial Infarction
Gene Expression
lcsh:Medicine
030204 cardiovascular system & hematology
Cardiovascular
0302 clinical medicine
Gene Frequency
Risk Factors
Polymorphism (computer science)
Genotype
Medicine
lcsh:Science
0303 health sciences
Multidisciplinary
biology
Genomics
PTX3
Middle Aged
Prognosis
Innate Immunity
3. Good health
Serum Amyloid P-Component
C-Reactive Protein
Female
Research Article
Genotypes
Immunology
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Molecular Genetics
03 medical and health sciences
Genetics
Humans
Genetic Predisposition to Disease
Genetic Testing
Biology
Allele frequency
Aged
030304 developmental biology
business.industry
Osmolar Concentration
lcsh:R
Haplotype
C-reactive protein
Immunity
Case-control study
Computational Biology
Human Genetics
Atherosclerosis
Case-Control Studies
biology.protein
lcsh:Q
business
Biomarkers
Blood Chemical Analysis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, Vol 7, Iss 12, p e53030 (2012), PLoS ONE, PLoS ONE; Vol 7
- Accession number :
- edsair.doi.dedup.....ec03461a627844c3d0cafb45acef4ad7