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Important Considerations for Sample Collection in Metabolomics Studies with a Special Focus on Applications to Liver Functions
- Source :
- Metabolites, Vol 10, Iss 3, p 104 (2020), Metabolites, Metabolites, MDPI, 2020, 10 (3), pp.104. ⟨10.3390/metabo10030104⟩
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- International audience; Metabolomics has found numerous applications in the study of liver metabolism in health and disease. Metabolomics studies can be conducted in a variety of biological matrices ranging from easily accessible biofluids such as urine, blood or feces, to organs, tissues or even cells. Sample collection and storage are critical steps for which standard operating procedures must be followed. Inappropriate sample collection or storage can indeed result in high variability, interferences with instrumentation or degradation of metabolites. In this review, we will first highlight important general factors that should be considered when planning sample collection in the study design of metabolomic studies, such as nutritional status and circadian rhythm. Then, we will discuss in more detail the specific procedures that have been described for optimal pre-analytical handling of the most commonly used matrices (urine, blood, feces, tissues and cells).
- Subjects :
- 0301 basic medicine
Computer science
Endocrinology, Diabetes and Metabolism
Operating procedures
[SDV]Life Sciences [q-bio]
High variability
lcsh:QR1-502
Review
Computational biology
01 natural sciences
Biochemistry
lcsh:Microbiology
03 medical and health sciences
Metabolomics
blood
Molecular Biology
standard operating procedures
010401 analytical chemistry
Nutritional status
tissue
metabolomics
urine
0104 chemical sciences
3. Good health
030104 developmental biology
Liver metabolism
feces
liver function
[SDV.TOX]Life Sciences [q-bio]/Toxicology
cells
Sample collection
Liver function
Liver functions
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Subjects
Details
- Language :
- English
- ISSN :
- 22181989
- Volume :
- 10
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Metabolites
- Accession number :
- edsair.doi.dedup.....ec119031fed77bb3d43ea5f561d99626