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Tumor-infiltrating platelets predict postoperative recurrence and survival in resectable pancreatic neuroendocrine tumor
- Source :
- World Journal of Gastroenterology
- Publication Year :
- 2019
- Publisher :
- Baishideng Publishing Group Inc., 2019.
-
Abstract
- BACKGROUND Platelets have been reported to participate in tumor cell growth, extravasation, epithelial–mesenchymal transition, metastasis, and drug resistance. However, the importance of platelets in pancreatic neuroendocrine tumor (pNET) lacks adequate literature support. The predictive value of tumor-infiltrating platelets (TIPs) in pNET remains unclear. AIM To investigate the relationship between TIPs and the prognosis of patients with pNET following radical resection. METHODS In total, 113 patients who had undergone radical surgical resection with a pathologic diagnosis of pNET were enrolled in this study. Immunohistochemical analysis of cluster of differentiation 42b (CD42b) expression in the tumor specimens was performed to determine the presence of TIPs. Univariate and multivariate analyses were used to analyze the prognostic value of TIPs. RESULTS TIPs were observed in intratumoral areas in 54 patients. Neither basic characteristics nor preoperative platelet-associated indicators showed a significant relationship with the presence of TIPs (all P > 0.05). Patients with positive intratumoral CD42b expression had worse overall survival (P = 0.005) and recurrence-free survival (P < 0.001) than those with negative intratumoral CD42b expression. Multivariate analysis demonstrated that TIPs were independent prognostic factors for overall survival (P = 0.049) and recurrence-free survival (P = 0.003). Nevertheless, platelet count, mean platelet volume, and platelet-to-lymphocyte ratio were not associated with postoperative survival or recurrence in pNET patients (all P > 0.05). CONCLUSION TIPs are a useful prognostic biomarker for patients with resectable pNET, and their detection represents a promising tool for pNET treatment strategy decisions.
- Subjects :
- Male
Oncology
Platelet count
Survival
Pancreatic neuroendocrine tumor
Drug resistance
Metastasis
0302 clinical medicine
Recurrence
Platelet
Lymphocytes
Postoperative Period
Neoplasm Metastasis
Aged, 80 and over
Tumor-infiltrating platelets
Gastroenterology
General Medicine
Middle Aged
Prognosis
Extravasation
Neuroendocrine Tumors
030220 oncology & carcinogenesis
Immunohistochemistry
Female
030211 gastroenterology & hepatology
Adult
Blood Platelets
medicine.medical_specialty
Epithelial-Mesenchymal Transition
Mean platelet volume
Disease-Free Survival
03 medical and health sciences
Retrospective Study
Internal medicine
medicine
Humans
Lymphocyte Count
Aged
Proportional Hazards Models
Retrospective Studies
Cluster of differentiation
business.industry
Platelet-to-lymphocyte ratio
medicine.disease
Pancreatic Neoplasms
Neoplasm Recurrence, Local
business
Biomarkers
Follow-Up Studies
Subjects
Details
- ISSN :
- 10079327
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- World Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....ec19c9c1a2402fbc8bfc7bde49688682