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Incidence of precancerous foci of mammary glands and growth rate of transplantable mammary cancers in sialoadenectomized mice
- Source :
- Journal of the National Cancer Institute. 81(21)
- Publication Year :
- 1989
-
Abstract
- Sialoadenectomies performed on 8-week-old female SHN and GR mice markedly reduced the numbers of precancerous and cancerous lesions in their mammary glands that had been mildly hypoplastic; the mice were necropsied when they were 30 weeks old. The success rate of the mammary cancer transplantation to isogenic male SHN or C3H mice was lower in the sialoadenectomized animals, and growth of the grafted tumors was delayed after gland removal. Some tumor development resumed in the hosts that received mouse epidermal growth factor after surgery. Therefore, we believe this growth factor may play a role in the multistage process of mouse mammary carcinogenesis.
- Subjects :
- Cancer transplantation
Male
Cancer Research
Pathology
medicine.medical_specialty
Mice, Inbred C3H
Epidermal Growth Factor
Incidence (epidemiology)
Growth factor
medicine.medical_treatment
Submandibular Gland
Mammary Neoplasms, Experimental
Biology
Mice
Oncology
Epidermal growth factor
medicine
Mammary carcinogenesis
Animals
Female
Precancerous Conditions
Mammary Cancers
Neoplasm Transplantation
Subjects
Details
- ISSN :
- 00278874
- Volume :
- 81
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- Journal of the National Cancer Institute
- Accession number :
- edsair.doi.dedup.....ec25d71b8ceb0ddca1d111df59d2a113