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Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer
Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer
- Source :
- World Journal of Gastroenterology
- Publication Year :
- 2020
- Publisher :
- Baishideng Publishing Group Inc, 2020.
-
Abstract
- BACKGROUND Systemic inflammation and nutrition status play an important role in cancer metastasis. The combined index of hemoglobin, albumin, lymphocyte, and platelet (HALP), consisting of haemoglobin, albumin, lymphocytes, and platelets, is considered as a novel marker to reflect both systemic inflammation and nutrition status. However, no studies have investigated the relationship between HALP and survival of patients with pancreatic cancer following radical resection. AIM To evaluate the prognostic value of preoperative HALP in pancreatic cancer patients. METHODS The preoperative serum levels of hemoglobin, albumin, lymphocyte counts, and platelet counts were routinely detected in 582 pancreatic adenocarcinoma patients who underwent radical resection. The relationship between postoperative survival and the preoperative level of HALP was investigated. RESULTS Low levels of HALP were significantly associated with lymph node metastasis (P = 0.002), poor tumor differentiation (P = 0.032), high TNM stage (P = 0.008), female patients (P = 0.005) and tumor location in the head of the pancreas (P < 0.001). Low levels of HALP were associated with early recurrence [7.3 mo vs 16.3 mo, P < 0.001 for recurrence-free survival (RFS)] and short survival [11.5 mo vs 23.6 mo, P < 0.001 for overall survival (OS)] in patients with resected pancreatic adenocarcinoma. A low level of HALP was an independent risk factor for early recurrence and short survival irrespective of sex and tumor location. CONCLUSION Low levels of HALP may be a significant risk factor for RFS and OS in patients with resected pancreatic cancer.
- Subjects :
- Adult
Blood Platelets
Male
medicine.medical_specialty
Lymphocyte
Nutritional Status
Adenocarcinoma
Systemic inflammation
Gastroenterology
03 medical and health sciences
Hemoglobins
0302 clinical medicine
Pancreatectomy
Retrospective Study
Predictive Value of Tests
Pancreatic cancer
Internal medicine
medicine
Humans
Platelet
Serum Albumin
Aged
Proportional Hazards Models
Aged, 80 and over
business.industry
Nutrition status
Platelet Count
Albumin
General Medicine
Middle Aged
medicine.disease
Postoperative survival
Prognosis
Pancreatic Neoplasms
medicine.anatomical_structure
Treatment Outcome
030220 oncology & carcinogenesis
HALP
Preoperative Period
030211 gastroenterology & hepatology
Female
medicine.symptom
business
Pancreatic adenocarcinoma
Subjects
Details
- Language :
- English
- ISSN :
- 22192840 and 10079327
- Volume :
- 26
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- World Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....ec2f27d57ba4d3524948d73f492cf683