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The fate of intravenous (3H)glycopyrrolate in man
- Source :
- The Journal of pharmacy and pharmacology. 26(5)
- Publication Year :
- 1974
-
Abstract
- Glycopyrrolate was labelled in one methyl group with tritium and its fate was studied in six patients with T-tube drainage by determining serum levels as well as the biliary and urinary excretion of radioactivity after intravenous injection. More than 90 % of the radioactivity had disappeared from serum in 5 min and after 30 min almost no radioactivity could be found. The highest radioactivity in bile was found in samples taken 30 or 60 min after the injection. However, measurable radioactivity was found in most cases after 48 h. The first urine samples (0–3 h) showed the greatest radioactivity, and in 48 h 85% of the total radioactivity was excreted into the urine. Paper chromatography showed that both in bile and in urine over 80% of the radioactivity corresponded to unchanged glycopyrrolate. That appreciable amounts of glycopyrrolate were excreted into the bile suggests that the spasmolysis achieved with glycopyrrolate could be based partly on a local action on the bile ducts.
- Subjects :
- Pharmacology
Male
medicine.medical_specialty
Pyrrolidines
Time Factors
Chemistry
Chromatography, Paper
Pharmaceutical Science
Parasympatholytics
Urine
Tritium
Glycopyrrolate
Quaternary Ammonium Compounds
Paper chromatography
Urinary excretion
Endocrinology
Internal medicine
Injections, Intravenous
medicine
Bile
Humans
Mandelic Acids
Female
Subjects
Details
- ISSN :
- 00223573
- Volume :
- 26
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The Journal of pharmacy and pharmacology
- Accession number :
- edsair.doi.dedup.....ec5127be64b07725b105a65945f07620