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Dihydromyricetin-rich herbal mixture extracts as a potential prescription for treatment of metabolic syndrome in rats fed a high-fat diet and subacute toxicity assessment in rats
- Source :
- Journal of Traditional and Complementary Medicine, Vol 9, Iss 3, Pp 221-226 (2019)
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- Dihydromyricetin (DHM)-rich herbal mixture extracts, also called APF complex, comprised of Ampelopsis grossedentata, Pericarpium citri reticulatae, and Fructus crataegi. The content of DHM in APF complex was 362.7 ± 12.5 mg/g. The aims of this study were to investigate the therapeutic effects of APF complex on metabolic syndrome in rats fed a high-fat diet (HFD) and evaluate the subacute toxicity of APF complex in rats. HFD significantly increased body weight gain, fat tissue (epididymal fat, mesenteric fat, and perirenal fat) deposition, body fat index, and hepatic triglyceride (TG) and total cholesterol (TC) accumulation as well as caused abnormal blood biochemical parameters, including TC, TG, low-density lipoprotein-cholesterol (LDL-C), free fatty acid (FFA), and glucose. APF complex has a tendency but not significance to limit HFD-induced body weight gain. APF complex also significantly improved HFD-induced body fat accumulation, as evidenced by decreasing fat tissue deposition and body fat index. In addition, APF complex significantly ameliorated HFD-induced hyperlipidemia and hyperglycemia, as evidenced by reducing levels of blood TG and TC as well as blood glucose and FFA, respectively. Furthermore, APF complex significantly decreased HFD-induced hepatic TG and TC accumulation. In subacute toxicity assessment, APF complex exhibited no toxicological signs, as evidenced by without affecting mortality, food and water consumption, body weight changes, absolute organ weights, hematological system, blood lipids and nutritional status, and electrolyte balance as well as non-toxic to liver and renal function. Overall, APF complex was considered as a non-toxic herbal prescription and could act as adjuvant therapy for metabolic syndrome. Keywords: Dihydromyricetin, Herbal mixture extracts, High-fat diet, Metabolic syndrome, Subacute toxicity
- Subjects :
- medicine.medical_specialty
ved/biology.organism_classification_rank.species
0211 other engineering and technologies
lcsh:Medicine
Adipose tissue
Blood lipids
02 engineering and technology
01 natural sciences
Adipose capsule of kidney
chemistry.chemical_compound
Internal medicine
021105 building & construction
Hyperlipidemia
medicine
chemistry.chemical_classification
Triglyceride
Chemistry
ved/biology
lcsh:R
Fatty acid
medicine.disease
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Endocrinology
Complementary and alternative medicine
lipids (amino acids, peptides, and proteins)
Original Article
Metabolic syndrome
Ampelopsis grossedentata
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Traditional and Complementary Medicine, Vol 9, Iss 3, Pp 221-226 (2019)
- Accession number :
- edsair.doi.dedup.....ec5b810030812af7ab82dbde28d4eb52