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Efficacy of Chinese herbal compound GAPT for the treatment of Alzheimer’s disease during mouse/rat studies: A systematic review and meta-analysis
- Source :
- Journal of Traditional Chinese Medical Sciences, Vol 6, Iss 4, Pp 294-307 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Objective: To evaluate the efficacy of the Chinese herbal compound GAPT for the treatment of Alzheimer’s disease (AD) and to provide current evidence for potential treatment mechanisms. Methods: A comprehensive search of PubMed, Embase, Web of Science, SinoMed, China Network Knowledge Infrastructure, Wanfang Data, and Chinese Scientific Journals Database was performed to identify GAPT mouse/rat studies published from inception to July 2019. The outcomes extracted were Morris water maze results and molecular biological quantifications. Results: A total of 19 studies were included in this analysis. The analysis indicated that GAPT was able to significantly improve learning and memory abilities compared with model mice/rats, as assessed by Morris water maze, and showed similar efficacy as donepezil. Subgroup analyses showed that low, medium, and high doses resulted in no obvious dose-dependent effects. Additionally, the GAPT group had significantly reduced expression levels of amyloid-beta peptide, presenilin 1, phosphorylated tau, acetylcholinesterase, and glycogen synthase kinase-3β, but increased expression levels of Shank1, and protein phosphatase-2A, and improved synapses structures compared with the model group, and subgroup analyses showed the medium dose of GAPT was superior to the low and high doses. Conclusions: Based on the pooled analysis, GAPT improved the learning and memory abilities and regulated the expression levels of related proteins during the progression of AD in mouse/rat studies. Notably, the medium dose of GAPT exhibited better performance than the other two doses, providing experimental evidence for further applications of GAPT during clinical practice. Keywords: Chinese herbal compound, Alzheimer’s disease, Mouse, Systematic review, Meta-analysis
- Subjects :
- 0303 health sciences
business.industry
Morris water navigation task
Disease
Pharmacology
lcsh:RZ409.7-999
030226 pharmacology & pharmacy
Acetylcholinesterase
Presenilin
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pooled analysis
Complementary and alternative medicine
chemistry
Meta-analysis
High doses
Medicine
business
Donepezil
lcsh:Miscellaneous systems and treatments
030304 developmental biology
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20957548
- Volume :
- 6
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Traditional Chinese Medical Sciences
- Accession number :
- edsair.doi.dedup.....ec640936fc39d83df10ce47e9f3e03ab