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Thermo-Tunable Pores and Antibiotic Gating Properties of Bovine Skin Gelatin Gels Prepared with Poly(n-isopropylacrylamide) Network
- Source :
- Polymers, Volume 12, Issue 9, Polymers, Vol 12, Iss 2156, p 2156 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Polystyrene nanospheres (PNs) were embedded in bovine skin gelatin gels with a poly(N-isopropylacrylamide) (PNIPAAm) network, which were denoted as NGHHs, to generate thermoresponsive behavior. When 265 nm PNs were exploited to generate the pores, bovine skin gelatin extended to completely occupy the pores left by PNs below the lower critical solution temperature (LCST), forming a pore-less structure. Contrarily, above the LCST, the collapse of hydrogen bonding between bovine skin gelatin and PNIPAAm occurred, resulting in pores in the NGHH. The behavior of pore closing and opening below and above the LCST, respectively, indicates the excellent drug gating efficiency. Amoxicillin (AMX) was loaded into the NGHHs as smart antibiotic gating due to the pore closing and opening behavior. Accordingly, E. coli. and S. aureus were exploited to test the bacteria inhibition ratio (BIR) of the AMX-loaded NGHHs. BIRs of NGHH without pores were 48% to 46.7% at 25 and 37 &deg<br />C, respectively, for E. coli during 12 h of incubation time. The BIRs of nanoporous NGHH could be enhanced from 61.5% to 90.4% providing a smart antibiotic gate of bovine skin gelatin gels against inflammation from infection or injury inflammation.
- Subjects :
- food.ingredient
Polymers and Plastics
Hydrogen bond
Nanoporous
General Chemistry
Gating
bovine skin gelatin
Gelatin
Lower critical solution temperature
Article
porous hydrogel
lcsh:QD241-441
polystyrene nanosphere
chemistry.chemical_compound
food
lcsh:Organic chemistry
chemistry
Chemical engineering
Poly(N-isopropylacrylamide)
poly(N-isopropylacrylamide)
Polystyrene
Porous hydrogel
Subjects
Details
- ISSN :
- 20734360
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Polymers
- Accession number :
- edsair.doi.dedup.....ec69c1afc3c4ad2d90d016d9758edc6d