Erythrocyte association and interferon production by minute virus of mice

SummaryMinute virus of mice was found to be closely associated with the erythrocyte fraction of the blood of infected mice, with peak viremia occurring on day 5 or 6 after intraperitoneal inoculation. The association with erythrocytes suggests a common mechanism of transplacental transport for the teratogenic Parvoviruses. In addition, MVM was found to be a relatively poor inducer of interferon and to be very sensitive to the inhibiting action of interferon.