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Impact of inter-amoebic phagocytosis on the L. pneumophila growth
Impact of inter-amoebic phagocytosis on the L. pneumophila growth
- Source :
- FEMS Microbiology Letters. 367
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Free-living amoebae are known to act as replication niches for the pathogenic bacterium Legionella pneumophila in freshwater environments. However, we previously reported that some strains of the Willaertia magna species are more resistant to L. pneumophila infection and differ in their ability to support its growth. From this observation, we hypothesize that L. pneumophila growth in environment could be partly dependent on the composition of amoebic populations and on the possible interactions between different amoebic species. We tested this hypothesis by studying the growth of L. pneumophila and of a permissive free-living amoeba, Vermamoeba vermiformis (formerly named Hartmannella vermiformis), in co-culture with or without other free-living amoebae (Acanthamoeba castellanii and W. magna). We demonstrate the occurrence of inter-amoebic phagocytosis with A. castellanii and W. magna being able to ingest V. vermiformis infected or not infected with L. pneumophila. We also found that L. pneumophila growth is strongly impacted by the permissiveness of each interactive amoeba demonstrating that L. pneumophila proliferation and spread are controlled, at least in part, by inter-amoebic interactions.
- Subjects :
- Permissiveness
food.ingredient
Phagocytosis
Biology
Microbiology
Legionella pneumophila
Hartmannella vermiformis
Amoeba (genus)
03 medical and health sciences
food
parasitic diseases
Genetics
Molecular Biology
030304 developmental biology
0303 health sciences
Amoebida
Host Microbial Interactions
030306 microbiology
bacterial infections and mycoses
biology.organism_classification
Coculture Techniques
respiratory tract diseases
bacteria
Acanthamoeba castellanii
Willaertia magna
Legionnaires' Disease
Water Microbiology
Bacteria
Subjects
Details
- ISSN :
- 15746968
- Volume :
- 367
- Database :
- OpenAIRE
- Journal :
- FEMS Microbiology Letters
- Accession number :
- edsair.doi.dedup.....ec83672a08c994df2d17dafaf5b1c345
- Full Text :
- https://doi.org/10.1093/femsle/fnaa147