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Circulating metabolites serve as diagnostic biomarkers for HER2‐positive breast cancer and have predictive value for trastuzumab therapy outcomes
- Source :
- Journal of Clinical Laboratory Analysis. 36
- Publication Year :
- 2022
- Publisher :
- Wiley, 2022.
-
Abstract
- Human epidermal growth factor receptor 2 (HER2)-positive is a particularly aggressive type of the breast cancer. Trastuzumab-based therapy is a standard treatment for HER2-positive breast cancer, but some patients are resistance to the therapy. There are no known diagnostic biomarkers to improve the early diagnosis of HER2-positive breast cancer and the clinical utility of trastuzumab therapy. Using ultrahigh-performance liquid time of flight mass spectrometry (UPLC-TOF-MS)-based serum metabolomics and multivariate statistical analysis, we investigated and identified the circulating metabolites L-arginine and arachidonic acid were elevated in trastuzumab-responsive and trastuzumab-resistant HER2-positive breast cancer patients, and increased until reaching their peaks in trastuzumab-resistant HER2-positive breast cancer patients. Moreover, an equation for assessing the risk scores based on linear logistic regression models involving L-arginine and arachidonic acid was created, which was beneficial for revealing metabolic changes in HER2-positive breast cancer and enhancing current trastuzumab-based therapy. In summary, we develop serum-based metabolic biomarkers for diagnosis of HER2-positive breast cancers and predicts the therapeutic effects of trastuzumab therapy.
- Subjects :
- Adult
Microbiology (medical)
Receptor, ErbB-2
Biochemistry (medical)
Clinical Biochemistry
Public Health, Environmental and Occupational Health
Breast Neoplasms
Hematology
Middle Aged
Trastuzumab
Prognosis
Medical Laboratory Technology
Antineoplastic Agents, Immunological
Case-Control Studies
Biomarkers, Tumor
Humans
Immunology and Allergy
Female
Aged
Subjects
Details
- ISSN :
- 10982825 and 08878013
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Laboratory Analysis
- Accession number :
- edsair.doi.dedup.....ec917f10a9cfe069ce66e5a531bd77ef