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LncRNA NBR2 suppresses migration and invasion of colorectal cancer cells by downregulating miRNA-21
- Source :
- Human Cell. 33:98-103
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- It has been reported that lncRNA NBR2 regulates cancer metabolism. We investigated the role of NBR2 in colorectal cancer. We found that NBR2 was downregulated in colorectal cancer tissues than in adjacent healthy tissues. Decreased expression levels of NBR2 in tumor tissues were observed with the increase of clinical stages. MiRNA-21 was upregulated in colorectal cancer tissues than in adjacent healthy tissues, and was significantly and inversely correlated with NBR2. NBR2 overexpression downregulated miRNA-21 in colorectal cancer cells, while miRNA-21 overexpression failed to significantly affect NBR2 expression. NBR2 overexpression suppressed migration and invasion of colorectal cancer cells. MiRNA-21 overexpression played an opposite role and attenuated the effects of NBR2 overexpression. NBR2 overexpression did not significantly alter cancer cell proliferation. Therefore, lncRNA NBR2 inhibited colorectal cancer cell migration and invasion possibly by downregulating miRNA-21.
- Subjects :
- 0301 basic medicine
Cancer Research
Colorectal cancer
Cancer cell proliferation
Cell migration
Cell Biology
Biology
medicine.disease
Tumor tissue
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Downregulation and upregulation
Cell Movement
030220 oncology & carcinogenesis
Cancer metabolism
microRNA
Cancer research
medicine
Humans
Neoplasm Invasiveness
RNA, Long Noncoding
Stem cell
Colorectal Neoplasms
Transcription Factors
Subjects
Details
- ISSN :
- 17490774
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Human Cell
- Accession number :
- edsair.doi.dedup.....eca00b9d3781e1aca8d54da0423927de