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A Pilot Study Evaluating the Effects of 670 nm Photobiomodulation in Healthy Ageing and Age-Related Macular Degeneration
- Source :
- Journal of Clinical Medicine, Vol 9, Iss 1001, p 1001 (2020), Journal of Clinical Medicine, Volume 9, Issue 4
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Limited evidence suggests that the application of 670 nm of red light alters the course of aged decline. A previous report on 18 patients showed regression of drusen and improvement in visual functions in patients with intermediate age-related macular degeneration (AMD) by 12 months. We evaluated the functional and structural effects of applying 670 nm light to 31 patients with intermediate AMD and 11 people aged 55 years or above with normal retina. The study eyes were treated daily in the morning with a 670 nm hand-held light source housed in a torch-like tube that emitted energy equivalent to 40 mW/cm2 or 4.8J/ cm2 for 2 min at the viewing aperture. Visual function in terms of best-corrected visual acuity, low luminance visual acuity, scotopic thresholds and rod-intercept time were compared between baseline and 1, 3, 6 and 12 months. Structural changes on optical coherence tomography OCT and colour photographs were also assessed. Five withdrew consent voluntarily due to the intensity of the study visit assessments and two developed neovascular AMD and were excluded from further treatment and the analysis. In normal ageing, there was an improvement in scotopic thresholds in the group with no AMD by 1.77dB (p = 0.03) and no other parameters showed any clinically significant change. In eyes with intermediate AMD, there was no significant improvement in any functional or structural changes at any time point up to 12 months although the compliance was good. This pilot study shows that photobiomodulation with 670 nm has no effect in patients who have already progressed to intermediate AMD.
- Subjects :
- medicine.medical_specialty
Visual acuity
genetic structures
lcsh:Medicine
subretinal drusenoid deposits
Drusen
Article
scotopic thresholds
03 medical and health sciences
0302 clinical medicine
Optical coherence tomography
Ophthalmology
photobiomodulation
medicine
Scotopic vision
age-related macular degeneration
Morning
optical coherence tomography
medicine.diagnostic_test
670 nm
business.industry
lcsh:R
reticular pseudodrusen
General Medicine
Macular degeneration
medicine.disease
dark adaptation
eye diseases
Ageing
030221 ophthalmology & optometry
Healthy ageing
sense organs
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 9
- Issue :
- 1001
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....ecb0cd96dc1230f291a543f74c7b9d5c