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Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020), Nature Communications
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group, 2020.
-
Abstract
- For newly diagnosed breast cancer, estrogen receptor status (ERS) is a key molecular marker used for prognosis and treatment decisions. During clinical management, ERS is determined by pathologists from immunohistochemistry (IHC) staining of biopsied tissue for the targeted receptor, which highlights the presence of cellular surface antigens. This is an expensive, time-consuming process which introduces discordance in results due to variability in IHC preparation and pathologist subjectivity. In contrast, hematoxylin and eosin (H&E) staining—which highlights cellular morphology—is quick, less expensive, and less variable in preparation. Here we show that machine learning can determine molecular marker status, as assessed by hormone receptors, directly from cellular morphology. We develop a multiple instance learning-based deep neural network that determines ERS from H&E-stained whole slide images (WSI). Our algorithm—trained strictly with WSI-level annotations—is accurate on a varied, multi-country dataset of 3,474 patients, achieving an area under the curve (AUC) of 0.92 for sensitivity and specificity. Our approach has the potential to augment clinicians’ capabilities in cancer prognosis and theragnosis by harnessing biological signals imperceptible to the human eye.<br />Determination of estrogen receptor status (ERS) in breast cancer tissue requires immunohistochemistry, which is sensitive to the vagaries of sample processing and the subjectivity of pathologists. Here the authors present a deep learning model that determines ERS from H&E stained tissue, which could improve oncology decisions in under-resourced settings.
- Subjects :
- 0301 basic medicine
Oncology
Receptors, Steroid
medicine.medical_specialty
Receptor Status
Science
H&E stain
General Physics and Astronomy
Breast Neoplasms
Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Breast cancer
Deep Learning
0302 clinical medicine
Internal medicine
Machine learning
Humans
Medicine
Receptor
lcsh:Science
Estrogen Receptor Status
Neoplasm Grading
Multidisciplinary
Staining and Labeling
business.industry
General Chemistry
medicine.disease
030104 developmental biology
Hormone receptor
Area Under Curve
030220 oncology & carcinogenesis
Immunohistochemistry
Female
lcsh:Q
business
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....ecbd8abede2793550aa3fbabaddeac6c