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Vascular Endothelial Growth Factor Produced in Nasal Glands of Perennial Allergic Rhinitis
- Source :
- American Journal of Rhinology. 22:365-370
- Publication Year :
- 2008
- Publisher :
- SAGE Publications, 2008.
-
Abstract
- Background Vascular endothelial growth factor (VEGF), a pleiotropic polypeptide that mediates endothelial cell-specific responses such as induction of angiogenesis and vascular leakage, is hyperproduced in a variety of inflammatory disorders. In asthma, VEGF hyperproduction promotes mucosal edema by enhancing vascular leakage. However, in allergic rhinitis, details of the pathophysiological importance remain unclear. This study was designed to investigate and discuss the pathophysiological significance of VEGF in nasal secretions from perennial allergic rhinitis sufferers. Methods Seven allergic rhinitis patients sensitized with house-dust mites and 12 chronic rhinosinusitis patients were enrolled. Nasal secretion VEGF was quantified and compared between groups. In allergic rhinitis cases, nasal lavage VEGF was estimated before and after the antigen provocation. Nasal gland VEGF was immunohistochemically investigated. VEGF messenger RNA (mRNA) levels in serous and mucous acini were analyzed by laser microdissection and light cycler-polymerase chain reaction. Results VEGF levels in nasal secretions and nasal lavage from allergic rhinitis were higher than in nonallergic rhinosinusitis, after rather than before antigen provocation. VEGF mRNA expression was higher in serous versus mucous acini. These results are consistent with the immunohistochemistry results. Conclusion In allergic rhinitis, there was significant VEGF production in serous acini, which was hypersecreted after antigen provocation. VEGF may play an important role in pathophysiology of allergic rhinitis.
- Subjects :
- Adult
Male
Vascular Endothelial Growth Factor A
Pathology
medicine.medical_specialty
Nasal Provocation Tests
Rhinitis, Allergic, Perennial
Perennial plant
Angiogenesis
medicine.medical_treatment
Gene Expression
Enzyme-Linked Immunosorbent Assay
Severity of Illness Index
chemistry.chemical_compound
medicine
Humans
RNA, Messenger
Laser capture microdissection
House dust mite
biology
Reverse Transcriptase Polymerase Chain Reaction
business.industry
Growth factor
Acute-phase protein
Nasal glands
Middle Aged
Nasal Lavage Fluid
biology.organism_classification
Immunohistochemistry
Vascular endothelial growth factor
Nasal Mucosa
Otorhinolaryngology
chemistry
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15396290 and 10506586
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- American Journal of Rhinology
- Accession number :
- edsair.doi.dedup.....ecc1d81d34056339136ae333c4a50e0b