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TAS2R38 taste receptor gene and chronic rhinosinusitis: a bitter ending

TAS2R38 taste receptor gene and chronic rhinosinusitis: a bitter ending

Authors :
Giorgio Binelli
Giulia Montrasio
Stefania Gallo
D Simmen
Paolo Castelnuovo
Paola Campomenosi
Raffaella Cinquetti
Sarah Grossi
Source :
Clinical and Translational Allergy
Publication Year :
2015
Publisher :
Wiley, 2015.

Abstract

Background Chronic rhinosinusitis (CRS) is a frequent disease with a high social impact and multifactorial pathogenesis. Recently, single nucleotide polymorphisms (SNPs) within the TAS2R38 gene were pointed at as possible contributors to the complex gene-environment interactions in CRS. This hypothesis was supported by in vitro evidence of the protective effect exerted by the functional bitter taste receptor T2R38 on sinonasal mucosa, due to its role in innate immunity. The purpose of this study was to confirm the proposed correlation between TAS2R38 genotype and CRS comorbidities and to assess whether the presence of a particular allele can be considered a prognostic marker.

Details

ISSN :
20457022
Volume :
5
Database :
OpenAIRE
Journal :
Clinical and Translational Allergy
Accession number :
edsair.doi.dedup.....ecd8b03b2176f248b601d64a2071256a
Full Text :
https://doi.org/10.1186/2045-7022-5-s4-p3