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TAS2R38 taste receptor gene and chronic rhinosinusitis: a bitter ending
TAS2R38 taste receptor gene and chronic rhinosinusitis: a bitter ending
- Source :
- Clinical and Translational Allergy
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Background Chronic rhinosinusitis (CRS) is a frequent disease with a high social impact and multifactorial pathogenesis. Recently, single nucleotide polymorphisms (SNPs) within the TAS2R38 gene were pointed at as possible contributors to the complex gene-environment interactions in CRS. This hypothesis was supported by in vitro evidence of the protective effect exerted by the functional bitter taste receptor T2R38 on sinonasal mucosa, due to its role in innate immunity. The purpose of this study was to confirm the proposed correlation between TAS2R38 genotype and CRS comorbidities and to assess whether the presence of a particular allele can be considered a prognostic marker.
Details
- ISSN :
- 20457022
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Clinical and Translational Allergy
- Accession number :
- edsair.doi.dedup.....ecd8b03b2176f248b601d64a2071256a
- Full Text :
- https://doi.org/10.1186/2045-7022-5-s4-p3