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Presence and actions of vasopressin-like peptides in the rabbit anterior uvea
- Source :
- Regulatory Peptides. 25:259-266
- Publication Year :
- 1989
- Publisher :
- Elsevier BV, 1989.
-
Abstract
- The presence of vasopressin-like immunoreactivity (VP-IR) in the rabbit eye was demonstrated by radioimmunoassay. Trigeminal nerve denervation resulted in a significant and selective decrease in the levels of VP-IR in the iris sphincter muscle and the cornea. The isolated iris sphincter muscle contracted in response to low concentrations of [Arg8]vasopressin (AVP) and related peptides. The V1 vasopressin receptor antagonist, d(CH2)5Tyr(Me)AVP, potently inhibited the contractile responses to AVP. AVP was found to induce an increase in the accumulation of inositol phosphates in the iris sphincter muscle but not in the dilator/ciliary body preparation in vitro. The present investigation demonstrates the presence of VP-IR in the rabbit eye and that this substance may be another sensory nerve-derived mediator acting on specific target sites in the anterior uvea.
- Subjects :
- Receptors, Vasopressin
Vasopressin
medicine.medical_specialty
Vasopressins
Physiology
Inositol Phosphates
Clinical Biochemistry
Iris sphincter muscle
Iris
Neuropeptide
Biology
Eye
Biochemistry
Cornea
Angiotensin Receptor Antagonists
Cellular and Molecular Neuroscience
Endocrinology
Ciliary body
Internal medicine
medicine
Animals
Trigeminal Nerve
Iris (anatomy)
Vasopressin receptor
Denervation
urogenital system
Ciliary Body
Arginine Vasopressin
medicine.anatomical_structure
Rabbits
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 01670115
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Regulatory Peptides
- Accession number :
- edsair.doi.dedup.....ecfa33a2f49b0c72c8331f1b6af4b8c6
- Full Text :
- https://doi.org/10.1016/0167-0115(89)90174-2