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Effect of Antihypertensive Drugs on Uric Acid Metabolism in Patients with Hypertension: Cross-Sectional Cohort Study
- Source :
- Drug Research. 66:628-632
- Publication Year :
- 2016
- Publisher :
- Georg Thieme Verlag KG, 2016.
-
Abstract
- Background: Hypertension is a common complication in patients with gout and/or hyperuricemia. Besides, hyperuricemia is a risk factor of gout as well as ischemic heart disease in hypertensive patients. Moreover, the risk of gout is modified by antihypertensive drugs. However, it remains unclear how antihypertensive agents affect uric acid metabolism. Purpose: In the present study, we investigated the uric acid metabolism in treated hypertensive patients to find out whether any of them would influence serum levels of uric acid. Patients and methods: 751 hypertensive patients (313 men and 438 women) under antihypertensive treatment were selected. Blood pressure (BP), serum uric acid (SUA) and serum creatinine (Scr) were measured and evaluated statistically. Results: In patients treated with diuretics, beta-blockers and/or alpha-1 blockers SUA levels were significantly higher than in patients who were not taking these drugs. Besides, the estimated glomerular filtration rate (eGFR) in patients treated with diuretics, beta-blockers and/or alpha-1 blockers was negatively correlated with SUA level. There were gender differences in the effects of beta-blockers and alpha-1 blockers. Multiple regression analysis indicated that both diuretics and beta-blockers significantly contributed to hyperuricemia in patients with medication for hypertension. Conclusion: Diuretics, beta-blockers and alpha-1 blockers reduced glomerular filtration rate and raised SUA levels. Calcium channel blockers, ACE inhibitors and angiotensin receptor blockers, including losartan, did not increase SUA levels.
- Subjects :
- Male
medicine.medical_specialty
Adrenergic beta-Antagonists
Renal function
Angiotensin-Converting Enzyme Inhibitors
Blood Pressure
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Gastroenterology
Losartan
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Drug Discovery
medicine
Humans
Hyperuricemia
Risk factor
Diuretics
Antihypertensive Agents
Creatinine
business.industry
nutritional and metabolic diseases
General Medicine
Calcium Channel Blockers
medicine.disease
Uric Acid
Gout
Cross-Sectional Studies
Endocrinology
Blood pressure
chemistry
Hypertension
Adrenergic alpha-1 Receptor Antagonists
Uric acid
Drug Therapy, Combination
Female
business
Glomerular Filtration Rate
medicine.drug
Subjects
Details
- ISSN :
- 21949387 and 21949379
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Drug Research
- Accession number :
- edsair.doi.dedup.....ecfb09b8faafd597b8e6ecac94752a2b