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Epigenetic targets of arsenic: emphasis on epigenetic modifications during carcinogenesis
- Source :
- Scopus-Elsevier
- Publication Year :
- 2015
-
Abstract
- DNA methylation and histone modification promote opening and closure of chromatin structure, which affects gene expression without altering the DNA sequence. Epigenetic markers regulate the dynamic nature of chromatin structure at different levels: DNA, histone, noncoding RNAs, as well as the higher-order chromatin structure. Accumulating evidence strongly suggests that arsenic-induced carcinogenesis involves frequent changes in the epigenetic marker. However, progress in identifying arsenic-induced epigenetic changes has already been made using genome-wide approaches; the biological significance of these epigenetic changes remains unknown. Moreover, arsenic-induced changes in the chromatin state alter gene expression through the epigenetic mechanism. The current review provides a summary of recent literature regarding epigenetic changes caused by arsenic in carcinogenesis. We highlight the transgenerational studies needed to explicate the biological significance and toxicity of arsenic over a broad spectrum.
- Subjects :
- Epigenetic regulation of neurogenesis
Carcinogenesis
Health, Toxicology and Mutagenesis
Biology
Toxicology
Chromatin remodeling
Pathology and Forensic Medicine
Arsenic
Epigenesis, Genetic
Histones
Mice
Epigenome editing
Animals
Humans
Cancer epigenetics
Epigenetics
Promoter Regions, Genetic
Epigenomics
Genetics
General Medicine
Epigenome
DNA Methylation
Chromatin
Cell biology
MicroRNAs
sense organs
Subjects
Details
- ISSN :
- 21626537
- Volume :
- 34
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
- Accession number :
- edsair.doi.dedup.....ed0cdd212bcc735538e0a3d2912897ff