Back to Search
Start Over
Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good
- Source :
- Human Genomics, Vol 13, Iss 1, Pp 1-13 (2019), Human Genomics
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- The field of pharmacogenomics (PGx) is gradually shifting from the reactive testing of single genes toward the proactive testing of multiple genes to improve treatment outcomes, reduce adverse events, and decrease the burden of unnecessary costs for healthcare systems. Despite the progress in the field of pharmacogenomics, its implementation into routine care has been slow due to several barriers. However, in recent years, the number of studies on the implementation of PGx has increased, all providing a wealth of knowledge on different solutions for overcoming the obstacles that have been emphasized over the past years. This review focuses on some of the challenges faced by these initiatives, the solutions and different approaches for testing that they suggest, and the evidence that they provide regarding the benefits of preemptive PGx testing.
- Subjects :
- lcsh:QH426-470
Computer science
Clinical Decision-Making
Treatment outcome
lcsh:Medicine
Review
Clinical decision support system
Translational Research, Biomedical
03 medical and health sciences
0302 clinical medicine
Drug Discovery
Genetics
Humans
Implementation of pharmacogenetics
Precision Medicine
PGx
Molecular Biology
Routine care
030304 developmental biology
Translation into the clinic
0303 health sciences
lcsh:R
Clinical decision support
Adversary
Decision Support Systems, Clinical
3. Good health
lcsh:Genetics
Treatment Outcome
Risk analysis (engineering)
Pharmacogenetics
030220 oncology & carcinogenesis
Pharmacogenomics
Molecular Medicine
Delivery of Health Care
Healthcare system
Subjects
Details
- Language :
- English
- ISSN :
- 14797364
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Human Genomics
- Accession number :
- edsair.doi.dedup.....ed0ffa3376651a9b33939c4da28fb370