Back to Search
Start Over
Patients Treated for Central Airway Stenosis After Lung Transplantation Have Persistent Airflow Limitation
- Source :
- Annals of Transplantation
- Publication Year :
- 2019
- Publisher :
- International Scientific Information, Inc., 2019.
-
Abstract
- BACKGROUND Although central airway stenosis (CAS) is a common complication after lung transplantation, its consequences have been poorly evaluated. The objective of our study was to evaluate the impact of CAS on lung function after lung transplantation. MATERIAL AND METHODS All lung transplant recipients from June 2009 to August 2014 in a single center (Strasbourg, France) were retrospectively reviewed. RESULTS A total of 191 lung transplantations were performed: 175 bilateral, 15 single, and 1 heart-lung transplantation. Of the 161 bilateral lung-transplanted patients who survived >3 months, 22 (13.6%) developed CAS requiring endobronchial treatment. All these patients were treated by endoscopic balloon dilatation, and 9 additionally needed endobronchial stents. Respiratory function tests demonstrated persistent obstructive ventilatory pattern despite endoscopic treatment in recipients with CAS compared to those without CAS at 6, 12, and 18 months post-transplant. At 18 months, CAS patients had significantly lower post-transplant FEV1 (1.96±0.60 L versus 2.57±0.76 L, p=0.001) and FEV1/FVC (61±14% versus 81±13%, p
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
030204 cardiovascular system & hematology
Single Center
03 medical and health sciences
FEV1/FVC ratio
Postoperative Complications
0302 clinical medicine
Bronchoscopy
medicine
Humans
Lung transplantation
Respiratory function
Retrospective Studies
Original Paper
Transplantation
Lung
business.industry
Respiratory infection
General Medicine
Middle Aged
respiratory system
Surgery
medicine.anatomical_structure
030228 respiratory system
Airway Remodeling
Female
Respiratory Insufficiency
Complication
business
Lung Transplantation
Subjects
Details
- ISSN :
- 23290358
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Annals of Transplantation
- Accession number :
- edsair.doi.dedup.....ed3fb37e00078aca1c596debfb96e30a