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Reporting elevated vancomycin minimum inhibitory concentration in methicillin-resistant Staphylococcus aureus: consensus by an International Working Group
- Source :
- Future Microbiology
- Publication Year :
- 2019
- Publisher :
- Future Medicine Ltd, 2019.
-
Abstract
- Methicillin-resistant Staphylococcus aureus (MRSA) remains an important cause of serious infection, for which vancomycin is often recommended as the first-choice antibiotic treatment. Appropriate vancomycin prescribing requires accurate measurement of minimum inhibitory concentrations (MICs) to avoid treatment failure, and yet determination can be challenging due to methodological difficulties associated with susceptibility testing. An International Working Group of infectious disease specialists and clinical/medical microbiologists reached a consensus that empirical MRSA infection therapies should be chosen regardless of the suspected origin of the infecting strain (e.g., community or hospital) due to the complex intermingling epidemiology of MRSA clones in these settings. Also, if an elevated vancomycin MIC in the susceptible range is obtained in routine testing, an alternative second method should be used for confirmation and to aid antibiotic therapy recommendations. There is no absolutely dependable method for the accurate determination of vancomycin MIC, but broth microdilution appears to be the most reliable.
- Subjects :
- Methicillin-Resistant Staphylococcus aureus
0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Consensus
HA-MRSA
Meticillin
medicine.drug_class
CA-MRSA
030106 microbiology
Antibiotics
Microbial Sensitivity Tests
Drug resistance
minimum inhibitory concentration
medicine.disease_cause
Microbiology
susceptibility
03 medical and health sciences
Minimum inhibitory concentration
Vancomycin
Internal medicine
medicine
Humans
Special Report
business.industry
Broth microdilution
Staphylococcal Infections
biochemical phenomena, metabolism, and nutrition
Methicillin-resistant Staphylococcus aureus
Anti-Bacterial Agents
030104 developmental biology
Staphylococcus aureus
business
medicine.drug
Subjects
Details
- ISSN :
- 17460921 and 17460913
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Future Microbiology
- Accession number :
- edsair.doi.dedup.....ed42a468744a411801b89948f6d116c8