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Distribution of sphingosine 1-phosphate, a bioactive sphingolipid, in rat tissues

Authors :
Yutaka Yatomi
Yasuyuki Igarashi
Robert J. Welch
Source :
FEBS Letters. 404:173-174
Publication Year :
1997
Publisher :
Wiley, 1997.

Abstract

Although a growing number of reports on the bioactivities of sphingosine 1-phosphate (Sph-1-P) in various systems have been appearing recently, current evidence for the involvement of Sph-1-P in signal transduction or cellular function(s) consists largely of data on cellular and biochemical effects of exogenous Sph-1-P. In this study, we measured Sph-1-P contents in various rat tissues. When the amount of this sphingoid base was measured by its N -acetylation into [ 3 H]C 2 -ceramide 1-phosphate with [ 3 H]acetic anhydride, we could detect Sph-1-P in all rat tissues examined. We also got unexpected findings that Sph-1-P exists most abundantly in testis=intestine>spleen (in the order of Sph-1-P abundance when its amounts were adjusted to the phospholipid levels). Our new data on Sph-1-P distribution in rat tissues may imply novel bioactivities for Sph-1-P. © 1997 Federation of European Biochemical Societies.

Details

ISSN :
00145793
Volume :
404
Database :
OpenAIRE
Journal :
FEBS Letters
Accession number :
edsair.doi.dedup.....ed44ae0076271e05f758f448b931c58c
Full Text :
https://doi.org/10.1016/s0014-5793(97)00121-x