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Ultrasound-Induced Magnetic Imaging of Tumors Targeted by Biofunctional Magnetic Nanoparticles
- Source :
- ACS nano. 11(3)
- Publication Year :
- 2017
-
Abstract
- Biofunctional magnetic nanoparticles (MNPs) have been widely applied in biomedical engineering. MNPs are used as a contrast medium in magnetic imaging. Current methods of magnetic imaging, such as magnetic particle imaging and magnetic relaxometry, use small amounts of MNPs at target points far from the surface of the patient's body; these methods always consume considerable power to produce magnetic fields of high uniformity or gradient excitations. Some drawbacks, such as a limited imaging region, imaging system shielding, and complex algorithms based on assumptions of MNP properties or environmental factors, also limit the application of MNP methods in clinics. Therefore, this work proposes an interdisciplinary methodology of ultrasound-induced magnetic imaging that lacks these drawbacks. In the proposed imaging method, magnet sets were designed with uniform magnetic fields to magnetize MNPs. Besides, magnetized MNPs are subjected to ultrasound vibrations; the motion of the MNPs induces weak induction voltages at the imaging pickup coils. The highly sensitive scanning superconducting quantum interference device biosusceptometry with three sets of ultrasound focus chips was developed to construct magnetic tomography at three depths. A phantom test showed favorable consistency between the visual photos and the magnetic images of alpha-fetoprotein antibody (anti-AFP) MNP distribution on gauzes. In animal tests, rats with liver tumors were imaged at the pre-injection and post-injection of anti-AFP MNPs. The consistent results of magnetic images and ultrasound images implied that the proposed method has high clinical potential.
- Subjects :
- 0301 basic medicine
Relaxometry
Materials science
General Physics and Astronomy
Nanotechnology
02 engineering and technology
Quantitative Biology::Cell Behavior
03 medical and health sciences
Magnetics
Magnetic particle imaging
Animals
General Materials Science
Magnetite Nanoparticles
Ultrasonography
business.industry
Ultrasound
Liver Neoplasms
General Engineering
021001 nanoscience & nanotechnology
Magnetic field
Rats
Contrast medium
030104 developmental biology
Magnetic Fields
Magnet
Electromagnetic shielding
Magnetic nanoparticles
alpha-Fetoproteins
0210 nano-technology
business
Subjects
Details
- ISSN :
- 1936086X
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- ACS nano
- Accession number :
- edsair.doi.dedup.....ed44c5e0f6826cf3e75ecfa42e5cb196