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Genomic imbalance defines three prognostic groups for risk stratification of patients with chronic lymphocytic leukemia
- Source :
- Leukemia & Lymphoma. 55:920-928
- Publication Year :
- 2013
- Publisher :
- Informa UK Limited, 2013.
-
Abstract
- Array comparative genomic hybridization (aCGH) has yet to be fully leveraged in a prognostic setting in chronic lymphocytic leukemia (CLL). Genomic imbalance was assessed in 288 CLL specimens using a targeted array. Based on 20 aberrations in a hierarchical manner, all 228 treatment-naive specimens were classified into a group with poor outcome (20.6%) exhibiting at least one aberration that was univariately associated with adverse outcome (gain: 2p, 3q, 8q, 17q, loss: 7q, 8p, 11q, 17p, 18p), good outcome (32.5%) showing 13q14 loss without any of the other 10 aberrations (gain: 1p, 7p, 12, 18p, 18q, 19, loss: 4p, 5p, 6q, 7p) or intermediate outcome (remainder). The three groups were significantly separated with respect to time to first treatment and overall survival (p < 0.001), and validation of the stratification scheme was performed in two independent datasets. Gain of 3q and 8q, and 17p loss were determined to be independent unfavorable prognostic biomarkers. TP53, NOTCH1 and SF3B1 mutations correlated with the presence of one poor outcome aCGH marker, at a considerably higher frequency than when only considering poor risk aberrations routinely detected by fluorescence in situ hybridization (FISH). These data support genomic imbalance evaluation in CLL by aCGH to assist in risk stratification.
- Subjects :
- Male
Oncology
Cancer Research
medicine.medical_specialty
Chronic lymphocytic leukemia
Datasets as Topic
Biology
Bioinformatics
Article
Molecular genetics
Internal medicine
Biomarkers, Tumor
medicine
Humans
Good outcome
In Situ Hybridization, Fluorescence
Neoplasm Staging
Chromosome Aberrations
Comparative Genomic Hybridization
Chromosomes, Human, Pair 13
Time to first treatment
Genomics
Hematology
Intermediate outcome
Prognosis
medicine.disease
Leukemia, Lymphocytic, Chronic, B-Cell
Patient Outcome Assessment
Mutation
Risk stratification
Female
Chromosome Deletion
Immunoglobulin Heavy Chains
Comparative genomic hybridization
Lymphoid leukemia
Subjects
Details
- ISSN :
- 10292403 and 10428194
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Leukemia & Lymphoma
- Accession number :
- edsair.doi.dedup.....ed46ae61d253427f30354a44f87fa7f3