Back to Search
Start Over
Going with the flow: insights from Caenorhabditis elegans zygote polarization
- Source :
- Philos Trans R Soc Lond B Biol Sci
- Publication Year :
- 2020
- Publisher :
- The Royal Society, 2020.
-
Abstract
- Cell polarity is the asymmetric distribution of cellular components along a defined axis. Polarity relies on complex signalling networks between conserved patterning proteins, including the PAR (partitioning defective) proteins, which become segregated in response to upstream symmetry breaking cues. Although the mechanisms that drive the asymmetric localization of these proteins are dependent upon cell type and context, in many cases the regulation of actomyosin cytoskeleton dynamics is central to the transport, recruitment and/or stabilization of these polarity effectors into defined subcellular domains. The transport or advection of PAR proteins by an actomyosin flow was first observed in theCaenorhabditis elegans zygote more than a decade ago. Since then a multifaceted approach, using molecular methods, high-throughput screens, and biophysical and computational models, has revealed further aspects of this flow and how polarity regulators respond to and modulate it. Here, we review recent findings on the interplay between actomyosin flow and the PAR patterning networks in the polarization of theC. eleganszygote. We also discuss how these discoveries and developed methods are shaping our understanding of other flow-dependent polarizing systems.This article is part of a discussion meeting issue ‘Contemporary morphogenesis’.
- Subjects :
- Physics
Zygote
Embryo, Nonmammalian
biology
Cell Polarity
Articles
Actomyosin
Protein Serine-Threonine Kinases
Polarization (waves)
biology.organism_classification
General Biochemistry, Genetics and Molecular Biology
Cell biology
Cytoplasmic streaming
Signalling
Cell polarity
Asymmetric cell division
Asymmetric distribution
Animals
General Agricultural and Biological Sciences
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Body Patterning
Signal Transduction
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Philos Trans R Soc Lond B Biol Sci
- Accession number :
- edsair.doi.dedup.....ed4aeadd71a02c5c505d1a69fdba313d