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Differential effect of brain-derived neurotrophic factor on high-threshold mechanosensitivity in a rat neuropathic pain model
- Source :
- Neuroscience letters. 278(1-2)
- Publication Year :
- 2000
-
Abstract
- We investigated the effect of the systemic infusion of brain derived neurotrophic factor (BDNF) on the behavioral response in a rat neuropathic pain model. One microgram per hour infusion of BDNF significantly attenuated mechanical hyperalgesia tested by the pin-prick test, however, 20 microg/h-BDNF infusion, on the contrary, enhanced the response. Neither 0.5 nor 10 microg/h-BDNF infusion influenced the mechanical hyperalgesia. Mechanical allodynia and thermal hyperalgesia, tested using a von Frey filament (23.0 mN) and the plantar test, were not influenced by BDNF treatment. These data suggest that systemic BDNF treatment can specifically alter high-threshold mechanosensitivity.
- Subjects :
- Male
medicine.medical_specialty
Hot Temperature
Microgram
Pain
Rats, Sprague-Dawley
Mechanical Hyperalgesia
Neurotrophic factors
Internal medicine
medicine
Animals
Infusions, Parenteral
Denervation
Brain-derived neurotrophic factor
business.industry
General Neuroscience
Brain-Derived Neurotrophic Factor
Recombinant Proteins
nervous system diseases
Rats
Endocrinology
Spinal Nerves
nervous system
Hyperalgesia
Von frey
Anesthesia
Sensory Thresholds
Neuropathic pain
Neuralgia
Stress, Mechanical
medicine.symptom
business
Mechanoreceptors
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 278
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....ed5acc7804420abd0efa6f4320b7741c