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Bacteria elevate extracellular adenosine to exploit host signaling for blood-brain barrier disruption
- Source :
- Virulence, Vol 11, Iss 1, Pp 980-994 (2020), Virulence, article-version (VoR) Version of Record
- Publication Year :
- 2020
- Publisher :
- Taylor & Francis Group, 2020.
-
Abstract
- Bacterial meningitis remains a substantial cause of mortality worldwide and survivors may have severe lifelong disability. Although we know that meningeal bacterial pathogens must cross blood-central nervous system (CNS) barriers, the mechanisms which facilitate the virulence of these pathogens are poorly understood. Here, we show that adenosine from a surface enzyme (Ssads) of Streptococcus suis facilitates this pathogen’s entry into mouse brains. Monolayer translocation assays (from the human cerebrovascular endothelium) and experiments using diverse inhibitors and agonists together demonstrate that activation of the A1 adenosine receptor signaling cascade in hosts, as well as attendant cytoskeleton remodeling, promote S. suis penetration across blood-CNS barriers. Importantly, our additional findings showing that Ssads orthologs from other bacterial species also promote their translocation across barriers suggest that exploitation of A1 AR signaling may be a general mechanism of bacterial virulence.
- Subjects :
- Microbiology (medical)
Nervous system
Virulence Factors
Immunology
Streptococcus suis
Virulence
Infectious and parasitic diseases
RC109-216
Blood–brain barrier
Microbiology
03 medical and health sciences
Mice
Bacterial Proteins
medicine
Extracellular
Animals
Humans
Pathogen
Cells, Cultured
030304 developmental biology
brain microvascular endothelial cell
0303 health sciences
biology
030306 microbiology
streptococcus suis
Brain
meningitis
blood-brain barrier
biology.organism_classification
central nervous system
Adenosine receptor
Adenosine
Cell biology
Mice, Inbred C57BL
Infectious Diseases
medicine.anatomical_structure
adenosine
Bacterial Translocation
Host-Pathogen Interactions
Parasitology
Female
streptococcus agalactiae
medicine.drug
Signal Transduction
Research Article
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 21505608 and 21505594
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Virulence
- Accession number :
- edsair.doi.dedup.....ed71dfb582511035b0e6085c3b3ba22e