Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy

Authors :: Michael Boele van Hensbroek
Martin Deijs
Menno D. de Jong
Linda Rosset Buluma
Cosimo Cristella
Maarten F. Jebbink
Richard Idro
Lia van der Hoek
Job B. M. van Woensel
Arthur W. D. Edridge
Irma Maurer
Ruth Namazzi
Neeltje A. Kootstra
Amsterdam Reproduction & Development (AR&D)
Graduate School
AII - Infectious diseases
APH - Global Health
ARD - Amsterdam Reproduction and Development
Medical Microbiology and Infection Prevention
Experimental Immunology
APH - Aging & Later Life
Paediatric Intensive Care
General Paediatrics
Global Health
Source :: Clinical Infectious Diseases, 68(1), 139-142. Oxford University Press, Clinical infectious diseases, 68(1), 139-142. Oxford University Press, Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, Clinical Infectious Diseases
Publication Year :: 2019
Abstract: A Ugandan child with an unexplained encephalitis was investigated using viral metagenomics. Several sequences from all segments of a novel orthobunyavirus were found. The S-segment, used for typing, showed 41% amino acid diversity to its closest relative. The virus was named Ntwetwe virus, after the hometown of the patient.

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