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Antibacterial polyvinyl alcohol/bacterial cellulose/nano-silver hydrogels that effectively promote wound healing
- Source :
- Materials scienceengineering. C, Materials for biological applications. 126
- Publication Year :
- 2020
-
Abstract
- The lack of antibacterial properties limits the application of bacterial cellulose hydrogels in wound dressings. To overcome this deficiency, silver nanoparticles (AgNPs) were introduced as antibacterial agents into a polyvinyl alcohol (PVA)/bacterial cellulose (BC) solution. A freeze-thaw method promoted formation of PVA/BC/Ag hydrogels and improved their mechanical properties. The physicochemical and biological properties of this hydrogel were systematically characterized. Those results showed the hydrogels contained a porous three-dimensional reticulum structure and had high mechanical properties. Also, the hydrogels possessed outstanding antibacterial properties and good biocompatibilities. More importantly, it effectively repaired wound defects in mice models and wound healing reached 97.89% within 15 days, and far exceeded other groups and indicated its potential for use in wound treatment applications.
- Subjects :
- Materials science
Silver
Biocompatibility
Metal Nanoparticles
Bioengineering
02 engineering and technology
010402 general chemistry
01 natural sciences
Polyvinyl alcohol
Silver nanoparticle
Biomaterials
chemistry.chemical_compound
Mice
Animals
Cellulose
Wound Healing
integumentary system
technology, industry, and agriculture
Silver Nano
Hydrogels
021001 nanoscience & nanotechnology
Antimicrobial
0104 chemical sciences
Anti-Bacterial Agents
Chemical engineering
chemistry
Mechanics of Materials
Bacterial cellulose
Polyvinyl Alcohol
Self-healing hydrogels
0210 nano-technology
Wound healing
Subjects
Details
- ISSN :
- 18730191
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- Materials scienceengineering. C, Materials for biological applications
- Accession number :
- edsair.doi.dedup.....ed7b8180d180ec80ffd3e81bdb51fa5f